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SERPINA1 [ficolin-1-rich granule lumen]
Stable Identifier
R-HSA-6804783
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
ficolin-1-rich granule lumen
Synonyms
Alpha-1-antitrypsin
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of ficolin-rich granule lumen proteins (Homo sapiens)
Ficolin-rich granule lumen proteins [ficolin-1-rich granule lumen] (Homo sapiens)
SERPINA1 [ficolin-1-rich granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01009 SERPINA1
Gene Names
SERPINA1, AAT, PI, PRO0684, PRO2209
Chain
signal peptide:1-24, chain:25-418, peptide:375-418
Reference Genes
BioGPS Gene:5265 SERPINA1
COSMIC (genes):SERPINA1 SERPINA1
CTD Gene:5265 SERPINA1
dbSNP Gene:5265 SERPINA1
ENSEMBL:ENSG00000197249 SERPINA1
HGNC:8941 SERPINA1
KEGG:hsa:5265 SERPINA1
Monarch:5265 SERPINA1
NCBI Gene:5265 SERPINA1
OMIM:107400 SERPINA1
UCSC:P01009 SERPINA1
Reference Transcript
RefSeq:NM_001127705.1 SERPINA1
RefSeq:NM_001127701.1 SERPINA1
RefSeq:NM_001127707.1 SERPINA1
RefSeq:NM_001127703.1 SERPINA1
RefSeq:NM_001127704.1 SERPINA1
RefSeq:NM_001002236.2 SERPINA1
RefSeq:NM_001002235.2 SERPINA1
RefSeq:NM_001127700.1 SERPINA1
RefSeq:NM_001127702.1 SERPINA1
RefSeq:NM_001127706.1 SERPINA1
RefSeq:XM_017021370.1 SERPINA1
RefSeq:NM_000295.4 SERPINA1
Other Identifiers
11721454_a_at
11721455_s_at
11721456_x_at
11721457_a_at
16796262
202833_PM_s_at
202833_s_at
211429_PM_s_at
211429_s_at
230318_PM_at
230318_at
3577624
3577625
3577626
3577627
3577628
3577629
3577630
3577631
3577632
3577633
3577635
3577636
3577637
3577638
3577639
3577640
3577641
3577642
3577643
3577644
3577646
3577647
3577648
3577649
3577650
3577651
3577652
36781_at
5265
68033_at
7981068
A_23_P218111
A_33_P3289659
GE523440
GE62796
GO:0002020
GO:0004867
GO:0005515
GO:0005576
GO:0005615
GO:0005783
GO:0005788
GO:0005794
GO:0006953
GO:0006954
GO:0007596
GO:0030134
GO:0030312
GO:0031012
GO:0031093
GO:0031410
GO:0033116
GO:0042802
GO:0043226
GO:0043231
GO:0062023
GO:0070062
GO:0098772
GO:1904813
HMNXSV003030416
HMNXSV003046236
Hs.297681.4.A1_3p_at
ILMN_1764980
ILMN_2256050
ILMN_2338452
ILMN_2404154
K01396_at
PH_hs_0028142
PH_hs_0036763
TC14001466.hg
TC14002135.hg
g4505792_3p_a_at
Participates
as a member of
Ficolin-rich granule lumen proteins [ficolin-1-rich granule lumen] (Homo sapiens)
Other forms of this molecule
SERPINA1 [endoplasmic reticulum lumen]
p-SERPINA1 [endoplasmic reticulum lumen]
SERPINA1 [extracellular region]
(Glc)3(GlcNAc)2(Man)9-SERPINA1 [endoplasmic reticulum lumen]
(Glc)3(GlcNAc)2(Man)9-SERPINA1 [COPII-coated ER to Golgi transport vesicle]
(Glc)3(GlcNAc)2(Man)9-SERPINA1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
SERPINA1 [platelet alpha granule lumen]
Inferred To
Spn28Da [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
Spn47C [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
Spn42Db [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
srp-1 [ficolin-1-rich granule lumen]
(Caenorhabditis elegans)
Spn28B [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
Spn55B [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
nec [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
Serpina1 [ficolin-1-rich granule lumen]
(Rattus norvegicus)
Spn85F [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
Spn75F [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
Spn88Eb [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
Homologues of SERPINA1 [ficolin-1-rich granule lumen]
(Caenorhabditis elegans)
Homologues of SERPINA1 [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
Homologues of SERPINA1 [ficolin-1-rich granule lumen]
(Mus musculus)
Homologues of SERPINA1 [ficolin-1-rich granule lumen]
(Sus scrofa)
Spn43Ab [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
Spn42Dc [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
srp-2 [ficolin-1-rich granule lumen]
(Caenorhabditis elegans)
Spn100A [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
Spn31A [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
si:ch211-186e20.7 [ficolin-1-rich granule lumen]
(Danio rerio)
srp-6 [ficolin-1-rich granule lumen]
(Caenorhabditis elegans)
Spn38F [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
Spn53F [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
Serpina1c [ficolin-1-rich granule lumen]
(Mus musculus)
Spn28F [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
Spn28Db [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
srp-3 [ficolin-1-rich granule lumen]
(Caenorhabditis elegans)
Spn42Dd [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
UABP-2 [ficolin-1-rich granule lumen]
(Sus scrofa)
srp-7 [ficolin-1-rich granule lumen]
(Caenorhabditis elegans)
Serpina1b [ficolin-1-rich granule lumen]
(Mus musculus)
Acp76A [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
Spn42Da [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
Spn43Ad [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
Spn42De [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
SERPINA1 [ficolin-1-rich granule lumen]
(Bos taurus)
SERPINA1 [ficolin-1-rich granule lumen]
(Caenorhabditis elegans)
SERPINA1 [ficolin-1-rich granule lumen]
(Canis familiaris)
SERPINA1 [ficolin-1-rich granule lumen]
(Gallus gallus)
SERPINA1 [ficolin-1-rich granule lumen]
(Sus scrofa)
srp-8 [ficolin-1-rich granule lumen]
(Caenorhabditis elegans)
Spn43Aa [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
Dmel\CG43366 [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
Spn88Ea [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
Spn27A [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001121179.1
,
NP_001002235.1
,
XP_016876859.1
,
NP_001002236.1
,
NP_000286.3
,
NP_001121174.1
,
NP_001121178.1
,
NP_001121176.1
,
NP_001121172.1
,
NP_001121175.1
,
NP_001121173.1
,
NP_001121177.1
OpenTargets
ENSG00000197249
ENSEMBL
ENSP00000416354
,
ENSP00000385960
,
ENST00000448921
,
ENST00000404814
,
ENSP00000408474
,
ENST00000449399
,
ENSP00000348068
,
ENSP00000490054
,
ENST00000440909
,
ENSP00000386094
,
ENSP00000376802
,
ENST00000437397
,
ENSP00000376803
,
ENST00000355814
,
ENST00000402629
,
ENSP00000390299
,
ENST00000393087
,
ENST00000393088
,
ENST00000636712
,
ENST00000489769
,
ENSP00000416066
,
ENSP00000451525
HPA
ENSG00000197249-SERPINA1
PRO
P01009
Pharos - Targets
P01009
GlyGen
P01009
Orphanet
SERPINA1
PDB
8PI2
,
1ATU
,
6ROD
,
1D5S
,
7NPK
,
8P4U
,
1EZX
,
1OPH
,
3T1P
,
7API
,
3DRM
,
4PYW
,
9API
,
2QUG
,
3DRU
,
1KCT
,
6I4V
,
1QLP
,
6IAY
,
1OO8
,
5IO1
,
3NDD
,
6I7U
,
8P4J
,
7NPL
,
3CWL
,
6HX4
,
3NDF
,
1IZ2
,
3NE4
,
8API
,
2D26
,
1PSI
,
3CWM
,
1QMB
,
7AEL
,
5NBU
,
5NBV
,
1HP7
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15393 TMPRSS2
2
TMPRSS2 [extracellular region]
(R-HSA-9681528)
TMPRSS2 [plasma membrane]
(R-HSA-9686707)
0.558
2
UniProt:P43307 SSR1
1
SSR1 [endoplasmic reticulum membrane]
(R-HSA-444588)
0.524
4
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