Reactome | TMPRSS2 [plasma membrane]

TMPRSS2 [plasma membrane]

Stable Identifier

R-HSA-9686707

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Transmembrane protease serine 2 ecNumber3.4.21.-/ecNumber, TMPS2_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O15393 TMPRSS2

Gene Names

TMPRSS2, PRSS10

Chain

chain:1-255, chain:256-492

Reference Genes

BioGPS Gene:7113 TMPRSS2

COSMIC (genes):TMPRSS2 TMPRSS2

CTD Gene:7113 TMPRSS2

dbSNP Gene:7113 TMPRSS2

ENSEMBL:ENSG00000184012 TMPRSS2

HGNC:11876 TMPRSS2

KEGG:hsa:7113 TMPRSS2

Monarch:7113 TMPRSS2

NCBI Gene:7113 TMPRSS2

OMIM:602060 TMPRSS2

UCSC:O15393 TMPRSS2

Reference Transcript

Participates

as an input of

TMPRSS2 binds TMPRSS2 inhibitors (Homo sapiens)

Other forms of this molecule

TMPRSS2 [extracellular region]

Cross References

RefSeq

XP_011528033.1, NP_005647.3, NP_001128571.1

Guide to Pharmacology - Targets

2421

OpenTargets

ENSG00000184012

ENSEMBL

ENST00000458356, ENSP00000391216, ENSP00000389006, ENST00000454499, ENSP00000503556, ENSG00000184012, ENSP00000330330, ENSP00000504705, ENSP00000502928, ENST00000679054, ENST00000332149, ENST00000678348, ENST00000398585, ENSP00000381588, ENST00000676973

ZINC - Substances

TMPS2_HUMAN

ZINC target

O15393

PRO

O15393

PDB

8VGT, 8YOY, 7XYD, 8V1F, 8Y1D, 7Y0F, 8YQQ, 8HD8, 8S0M, 8S0L, 8S0N, 8Y8B, 8JHZ, 9IZN, 7MEQ, 8V04, 8Y7X, 8Y87, 8Y89, 8Y88, 8Y7Y, 8Y8A, 7Y0E, 8Y1E, 8JI0

IntEnz

3.4.21.122

HPA

ENSG00000184012-TMPRSS2

GeneCards

TMPRSS2

Pharos - Targets

O15393

ZINC - Predictions - Purchasable

TMPS2_HUMAN

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01009 SERPINA1	8	SERPINA1 [platelet alpha granule lumen] (R-HSA-141755) SERPINA1 [extracellular region] (R-HSA-141757) SERPINA1 [endoplasmic reticulum lumen] (R-HSA-8956709) p-SERPINA1 [endoplasmic reticulum lumen] (R-HSA-8957062) (Glc)3(GlcNAc)2(Man)9-SERPINA1 [endoplasmic reticulum lumen] (R-HSA-5689435) (Glc)3(GlcNAc)2(Man)9-SERPINA1 [COPII-coated ER to Golgi transport vesicle] (R-HSA-5689731) (Glc)3(GlcNAc)2(Man)9-SERPINA1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689734) SERPINA1 [ficolin-1-rich granule lumen] (R-HSA-6804783)	0.558	2
UniProt:Q9BYF1 ACE2	5	glycosylated-ACE2 [plasma membrane] (R-HSA-9683480) ACE2 [endocytic vesicle membrane] (R-HSA-9698958) glycosylated-ACE2 [endocytic vesicle membrane] (R-HSA-9686721) ACE2 [endoplasmic reticulum lumen] (R-HSA-9683474) ACE2(18-805) [plasma membrane] (R-HSA-2022344)	0.463	3

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