activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin

Stable Identifier
R-HSA-141046
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin
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Activated thrombin (factor IIa) binds to thrombomodulin at the external face of the plasma membrane, forming a thrombin:thrombomodulin complex. In this complexed form, the activity of thrombin towards protein C is greatly increased, and as thrombomodulin is particularly abundant on the surfaces of endothelial cells, this association plays a major role in restricting clot formation.
Literature References
PubMed ID Title Journal Year
2538457 The roles of protein C and thrombomodulin in the regulation of blood coagulation

Esmon, CT

J Biol Chem 1989
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Orthologous Events
activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Bos taurus)
activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Canis familiaris)
activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Mus musculus)
activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Rattus norvegicus)
activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Sus scrofa)
Authored
D'Eustachio, P  (2004-08-26)
Created
D'Eustachio, P  (2004-08-26)
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