activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin

Stable Identifier
R-HSA-141046
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Activated thrombin (factor IIa) binds to thrombomodulin at the external face of the plasma membrane, forming a thrombin:thrombomodulin complex. In this complexed form, the activity of thrombin towards protein C is greatly increased, and as thrombomodulin is particularly abundant on the surfaces of endothelial cells, this association plays a major role in restricting clot formation.

Literature References
PubMed ID Title Journal Year
2538457 The roles of protein C and thrombomodulin in the regulation of blood coagulation

Esmon, CT

J Biol Chem 1989
Participants
Participant Of
Orthologous Events
Authored
Created