Reactome | activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin

activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin

Stable Identifier

R-HSA-141046

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin

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Activated thrombin (factor IIa) binds to thrombomodulin at the external face of the plasma membrane, forming a thrombin:thrombomodulin complex. In this complexed form, the activity of thrombin towards protein C is greatly increased, and as thrombomodulin is particularly abundant on the surfaces of endothelial cells, this association plays a major role in restricting clot formation.

Literature References

PubMed ID	Title	Journal	Year
26468766	Thrombomodulin Binding Selects the Catalytically Active Form of Thrombin Handley, LD, Treuheit, NA, Venkatesh, VJ, Komives, EA	Biochemistry	2015
2538457	The roles of protein C and thrombomodulin in the regulation of blood coagulation Esmon, CT	J Biol Chem	1989
22482044	Thrombomodulin: a bifunctional modulator of inflammation and coagulation in sepsis Okamoto, T, Tanigami, H, Suzuki, K, Shimaoka, M	Crit Care Res Pract	2012