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About
What is Reactome ?
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Team
Scientific Advisory Board
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Release Calendar
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
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ORCID Integration Project
COVID-19 Disease Pathways
Docs
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FGF19 [extracellular region]
Stable Identifier
R-HSA-189888
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Fibroblast growth factor-19, FGFJ_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4:pY-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR4 (Homo sapiens)
Downstream signaling of activated FGFR4 (Homo sapiens)
FRS-mediated FGFR4 signaling (Homo sapiens)
Activated FGFR4 binds FRS2 (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 binds FRS3 (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 phosphorylates FRS2 (Homo sapiens)
Activated FGFR4:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:p-8T-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 phosphorylates FRS3 (Homo sapiens)
Activated FGFR4:FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 phosphorylates PPTN11 (Homo sapiens)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:p-FRS bind to PPTN11 (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:p-FRS binds GRB2:SOS1 (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
PI-3K cascade:FGFR4 (Homo sapiens)
Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Phospholipase C-mediated cascade; FGFR4 (Homo sapiens)
Activated FGFR4 binds PLCG1 (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
activated FGFR4:PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 phosphorylates PLCG1 (Homo sapiens)
activated FGFR4:PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
activated FGFR4:p-4Y-PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
p-4Y-PLCG1 dissociates from activated FGFR4 (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
activated FGFR4:p-4Y-PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
SHC-mediated cascade:FGFR4 (Homo sapiens)
Activated FGFR4 binds SHC1 (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 phosphorylates SHC1 (Homo sapiens)
Activated FGFR4:SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:pY-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Homo sapiens)
Activated FGFR4:pY-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4:pY-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4:pY-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
FGFR4 ligand binding and activation (Homo sapiens)
Autocatalytic phosphorylation of FGFR4 (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
FGFR4 homodimer bound to FGF [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
FGFR4 binds to FGF (Homo sapiens)
FGFR4 homodimer bound to FGF [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
betaKlotho-mediated ligand binding (Homo sapiens)
Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
FGFR4:HS:KLB:FGF19 [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
FGFR4 binds HS:KLB:FGF19 (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
FGFR4:HS:KLB:FGF19 [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Negative regulation of FGFR4 signaling (Homo sapiens)
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Homo sapiens)
Activated FGFR4:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:p-8T-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
CBL ubiquitinates FRS2 and FGFR4 (Homo sapiens)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Ub-Activated FGFR4 complex:Ub-p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Homo sapiens)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
Activated FGFR bound to PI3K [cytosol] (Homo sapiens)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
IRS-related events triggered by IGF1R (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
Activated FGFR bound to PI3K [cytosol] (Homo sapiens)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
Activated FGFR4 homodimer [plasma membrane] (Homo sapiens)
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
FGF19 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95750 FGF19
Gene Names
FGF19, UNQ334/PRO533
Chain
signal peptide:1-24, chain:25-216
Reference Genes
BioGPS Gene:9965 FGF19
COSMIC (genes):FGF19 FGF19
CTD Gene:9965 FGF19
dbSNP Gene:9965 FGF19
ENSEMBL:ENSG00000162344 FGF19
ENSEMBL:ENSG00000162344.4 FGF19
HGNC:3675 FGF19
KEGG Gene (Homo sapiens):9965 FGF19
Monarch:9965 FGF19
NCBI Gene:9965 FGF19
OMIM:603891 FGF19
UCSC:O95750 FGF19
Reference Transcript
RefSeq:NM_005117.2 FGF19
Other Identifiers
11731165_at
16741393
223761_PM_at
223761_at
3380128
3380129
3380130
3380131
3380132
3380133
3380134
3380138
3380139
3380140
48270_at
7950023
9965
A_23_P427587
A_23_P52714
GE80672
GO:0001755
GO:0001934
GO:0005104
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0006629
GO:0007399
GO:0007507
GO:0008083
GO:0008284
GO:0008543
GO:0009617
GO:0009887
GO:0010628
GO:0010629
GO:0014070
GO:0015721
GO:0023052
GO:0030154
GO:0030334
GO:0036211
GO:0045471
GO:0046326
GO:0046330
GO:0048018
GO:0048856
GO:0048870
GO:0055085
GO:0070374
GO:0070858
GO:0098772
HMNXSV003008439
ILMN_1760909
PH_hs_0013216
TC11002018.hg
g5668600_3p_at
g5668600_3p_x_at
Participates
as an input of
FGFR4 binds HS:KLB:FGF19 (Homo sapiens)
as a component of
FGFR4:HS:KLB:FGF19 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
as a member of
FGFR4-binding FGFs [extracellular region] (Homo sapiens)
Inferred To
Fgf19 [extracellular region]
(Rattus norvegicus)
let-756 [extracellular region]
(Caenorhabditis elegans)
FGF19 [extracellular region]
(Bos taurus)
FGF19 [extracellular region]
(Canis familiaris)
FGF19 [extracellular region]
(Danio rerio)
FGF19 [extracellular region]
(Gallus gallus)
FGF19 [extracellular region]
(Sus scrofa)
fgf19 [extracellular region]
(Xenopus tropicalis)
Fgf15 [extracellular region]
(Mus musculus)
bnl [extracellular region]
(Drosophila melanogaster)
Cross References
RefSeq
NP_005108.1
OpenTargets
ENSG00000162344
GeneCards
O95750
HPA
ENSG00000162344-FGF19
Ensembl
ENST00000294312
,
ENSG00000162344
,
ENSP00000294312
PRO
O95750
Pharos - Targets
O95750
HMDB Protein
HMDBP12677
PDB
1PWA
,
6KTR
,
6NFJ
,
2P23
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