Autocatalytic phosphorylation of BetaKlotho-bound FGFR4

Stable Identifier
R-HSA-1307963
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
Synonyms
Autocatalytic phosphorylation of betaKlotho-bound FGFR4
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Autocatalytic phosphorylation of BetaKlotho-bound FGFR4
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After being bound by BetaKlotho and FGF19, FGFR4 undergoes autophosphorylation on tyrosine residues in the intracellular portion of the receptor. The phosphorylation sites on FGFR4 have not been accurately determined in vitro or in vivo but are predicted based on sequence comparison with the other FGF receptors.

Literature References
PubMed ID Title Journal Year
8622701 Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction

Mohammadi, M, Dikic, I, Sorokin, A, Burgess, WH, Jaye, M, Schlessinger, J

Mol Cell Biol 1996
19063940 The Klotho gene family as a regulator of endocrine fibroblast growth factors

Kurosu, H, Kuro-O, M

Mol Cell Endocrinol 2009
17623664 Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

Kurosu, H, Choi, M, Ogawa, Y, Dickson, AS, Goetz, R, Eliseenkova, AV, Mohammadi, M, Rosenblatt, KP, Kliewer, SA, Kuro-O, M

J Biol Chem 2007
20080590 Relevant use of Klotho in FGF19 subfamily signaling system in vivo

Tomiyama, K, Maeda, R, Urakawa, I, Yamazaki, Y, Tanaka, T, Ito, S, Nabeshima, Y, Tomita, T, Odori, S, Hosoda, K, Nakao, K, Imura, A, Nabeshima, Y

Proc Natl Acad Sci U S A 2010
1379698 Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis

Mohammadi, M, Dionne, CA, Li, W, Li, N, Spivak, T, Honegger, AM, Jaye, M, Schlessinger, J

Nature 1992
17339340 Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members

Goetz, R, Beenken, A, Ibrahimi, OA, Kalinina, J, Olsen, SK, Eliseenkova, AV, Xu, C, Neubert, TA, Zhang, F, Linhardt, RJ, Yu, X, White, KE, Inagaki, T, Kliewer, SA, Yamamoto, M, Kurosu, H, Ogawa, Y, Kuro-O, M, Lanske, B, Razzaque, MS, Mohammadi, M

Mol Cell Biol 2007
1656221 A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1

Mohammadi, M, Honegger, AM, Rotin, D, Fischer, R, Bellot, F, Li, W, Dionne, CA, Jaye, M, Rubinstein, M, Schlessinger, J

Mol Cell Biol 1991
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of FGFR4:HS:KLB:FGF19 [plasma membrane]
Physical Entity
FGFR4:HS:KLB:FGF19 [plasma membrane]
Activity
protein tyrosine kinase activity (0004713)
Orthologous Events
Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Bos taurus)
Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Canis familiaris)
Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Danio rerio)
Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Gallus gallus)
Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Mus musculus)
Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Rattus norvegicus)
Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Sus scrofa)
Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Xenopus tropicalis)
Authored
Rothfels, K  (2011-08-15)
Reviewed
Gotoh, N  (2011-08-26)
Created
Rothfels, K  (2011-05-30)