Reactome | Autocatalytic phosphorylation of BetaKlotho-bound FGFR4

Autocatalytic phosphorylation of BetaKlotho-bound FGFR4

Stable Identifier

R-HSA-1307963

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

Synonyms

Autocatalytic phosphorylation of betaKlotho-bound FGFR4

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by FGFR (Homo sapiens)
    - Signaling by FGFR4 (Homo sapiens)
      - FGFR4 ligand binding and activation (Homo sapiens)
        
        betaKlotho-mediated ligand binding (Homo sapiens)
        
        Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Homo sapiens)

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Autocatalytic phosphorylation of BetaKlotho-bound FGFR4

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After being bound by BetaKlotho and FGF19, FGFR4 undergoes autophosphorylation on tyrosine residues in the intracellular portion of the receptor. The phosphorylation sites on FGFR4 have not been accurately determined in vitro or in vivo but are predicted based on sequence comparison with the other FGF receptors.

Literature References

PubMed ID	Title	Journal	Year
8622701	Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction Mohammadi, M, Dikic, I, Sorokin, A, Burgess, WH, Jaye, M, Schlessinger, J	Mol Cell Biol	1996
19063940	The Klotho gene family as a regulator of endocrine fibroblast growth factors Kurosu, H, Kuro-O, M	Mol Cell Endocrinol	2009
17623664	Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21 Kurosu, H, Choi, M, Ogawa, Y, Dickson, AS, Goetz, R, Eliseenkova, AV, Mohammadi, M, Rosenblatt, KP, Kliewer, SA, Kuro-O, M	J Biol Chem	2007
20080590	Relevant use of Klotho in FGF19 subfamily signaling system in vivo Tomiyama, K, Maeda, R, Urakawa, I, Yamazaki, Y, Tanaka, T, Ito, S, Nabeshima, Y, Tomita, T, Odori, S, Hosoda, K, Nakao, K, Imura, A, Nabeshima, Y	Proc Natl Acad Sci U S A	2010
1379698	Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis Mohammadi, M, Dionne, CA, Li, W, Li, N, Spivak, T, Honegger, AM, Jaye, M, Schlessinger, J	Nature	1992
17339340	Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members Goetz, R, Beenken, A, Ibrahimi, OA, Kalinina, J, Olsen, SK, Eliseenkova, AV, Xu, C, Neubert, TA, Zhang, F, Linhardt, RJ, Yu, X, White, KE, Inagaki, T, Kliewer, SA, Yamamoto, M, Kurosu, H, Ogawa, Y, Kuro-O, M, Lanske, B, Razzaque, MS, Mohammadi, M	Mol Cell Biol	2007
1656221	A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1 Mohammadi, M, Honegger, AM, Rotin, D, Fischer, R, Bellot, F, Li, W, Dionne, CA, Jaye, M, Rubinstein, M, Schlessinger, J	Mol Cell Biol	1991