Autocatalytic phosphorylation of BetaKlotho-bound FGFR4

Stable Identifier
Reaction [transition]
Homo sapiens
Autocatalytic phosphorylation of betaKlotho-bound FGFR4
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After being bound by BetaKlotho and FGF19, FGFR4 undergoes autophosphorylation on tyrosine residues in the intracellular portion of the receptor. The phosphorylation sites on FGFR4 have not been accurately determined in vitro or in vivo but are predicted based on sequence comparison with the other FGF receptors.
Literature References
PubMed ID Title Journal Year
19063940 The Klotho gene family as a regulator of endocrine fibroblast growth factors

Kuro-O, M, Kurosu, H

Mol Cell Endocrinol 2009
8622701 Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction

Burgess, WH, Jaye, M, Schlessinger, J, Sorokin, A, Dikic, I, Mohammadi, M

Mol Cell Biol 1996
17623664 Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

Kuro-O, M, Eliseenkova, AV, Goetz, R, Kliewer, SA, Ogawa, Y, Dickson, AS, Kurosu, H, Mohammadi, M, Choi, M, Rosenblatt, KP

J Biol Chem 2007
20080590 Relevant use of Klotho in FGF19 subfamily signaling system in vivo

Tanaka, T, Yamazaki, Y, Nakao, K, Tomita, T, Urakawa, I, Nabeshima, Y, Odori, S, Nabeshima, Y, Maeda, R, Ito, S, Imura, A, Hosoda, K, Tomiyama, K

Proc Natl Acad Sci U S A 2010
1379698 Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis

Dionne, CA, Jaye, M, Li, N, Schlessinger, J, Honegger, AM, Mohammadi, M, Spivak, T, Li, W

Nature 1992
17339340 Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members

Eliseenkova, AV, Goetz, R, Zhang, F, Razzaque, MS, Ogawa, Y, Linhardt, RJ, Kurosu, H, Yamamoto, M, Kuro-O, M, Lanske, B, Beenken, A, Kalinina, J, Kliewer, SA, White, KE, Yu, X, Inagaki, T, Mohammadi, M, Xu, C, Olsen, SK, Ibrahimi, OA, Neubert, TA

Mol Cell Biol 2007
1656221 A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1

Bellot, F, Dionne, CA, Jaye, M, Schlessinger, J, Rotin, D, Honegger, AM, Rubinstein, M, Mohammadi, M, Fischer, R, Li, W

Mol Cell Biol 1991
Catalyst Activity

protein tyrosine kinase activity of FGFR4:HS:KLB:FGF19 [plasma membrane]

Orthologous Events
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