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About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
User Guide
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
Data Model
Computational inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
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KLB
Stable Identifier
R-HSA-1307932
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
BetaKlotho
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4:pY-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR4 (Homo sapiens)
Downstream signaling of activated FGFR4 (Homo sapiens)
FRS-mediated FGFR4 signaling (Homo sapiens)
Activated FGFR4 binds FRS2 (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4 binds FRS3 (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4 phosphorylates FRS2 (Homo sapiens)
Activated FGFR4:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-8T-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4 phosphorylates FRS3 (Homo sapiens)
Activated FGFR4:FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4 phosphorylates PPTN11 (Homo sapiens)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS bind to PPTN11 (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS binds GRB2:SOS1 (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
PI-3K cascade:FGFR4 (Homo sapiens)
Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Phospholipase C-mediated cascade; FGFR4 (Homo sapiens)
Activated FGFR4 binds PLCG1 (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
activated FGFR4:PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4 phosphorylates PLCG1 (Homo sapiens)
activated FGFR4:PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
activated FGFR4:p-4Y-PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
p-4Y-PLCG1 dissociates from activated FGFR4 (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
activated FGFR4:p-4Y-PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
SHC-mediated cascade:FGFR4 (Homo sapiens)
Activated FGFR4 binds SHC1 (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4 phosphorylates SHC1 (Homo sapiens)
Activated FGFR4:SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:pY-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Homo sapiens)
Activated FGFR4:pY-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4:pY-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4:pY-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
FGFR4 ligand binding and activation (Homo sapiens)
betaKlotho-mediated ligand binding (Homo sapiens)
Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
FGFR4:HS:KLB:FGF19 [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
FGFR4 binds HS:KLB:FGF19 (Homo sapiens)
FGFR4:HS:KLB:FGF19 [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Negative regulation of FGFR4 signaling (Homo sapiens)
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Homo sapiens)
Activated FGFR4:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-8T-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
CBL ubiquitinates FRS2 and FGFR4 (Homo sapiens)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Ub-Activated FGFR4 complex:Ub-p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Homo sapiens)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [plasma membrane, cytosol, endosome membrane] (Homo sapiens)
Activated FGFR bound to PI3K [plasma membrane] (Homo sapiens)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
IRS-related events triggered by IGF1R (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [plasma membrane, cytosol, endosome membrane] (Homo sapiens)
Activated FGFR bound to PI3K [plasma membrane] (Homo sapiens)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86Z14 KLB
Gene Names
KLB
Chain
chain:1-1044
Reference Genes
BioGPS Gene:152831 KLB
COSMIC (genes):KLB KLB
CTD Gene:152831 KLB
dbSNP Gene:152831 KLB
ENSEMBL:ENSG00000134962 KLB
ENSEMBL:ENSG00000134962 KLB
HGNC:15527 KLB
KEGG Gene (Homo sapiens):hsa:152831 KLB
Monarch:152831 KLB
NCBI Gene:152831 KLB
OMIM:611135 KLB
UCSC:Q86Z14 KLB
Reference Transcript
RefSeq:NM_175737.3 KLB
Other Identifiers
0002100546
11730624_at
11730625_at
11730626_at
152831
16966127
21136
235708_at
244276_at
2724314
2724319
2724320
2724321
2724322
2724324
2724325
2724326
2724327
2724328
2724329
2724330
2724331
2724334
2724335
2724336
2724337
48338_at
53621_at
77001_at
8094679
A_23_P350617
A_23_P69531
A_32_P33114
AAI04872
AAI13654
AB079373
BAC56857
BC104871
BC113653
CCDS3451
ENSG00000134962
ENSP00000257408
ENST00000257408
EntrezGene:152831
GE574265
GO:0000165
GO:0003674
GO:0004553
GO:0005088
GO:0005104
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005886
GO:0005887
GO:0005975
GO:0006464
GO:0006629
GO:0007165
GO:0008150
GO:0008283
GO:0008284
GO:0008543
GO:0009058
GO:0016020
GO:0016021
GO:0016301
GO:0016303
GO:0016798
GO:0017134
GO:0019899
GO:0036092
GO:0046854
GO:0046934
GO:0051897
GO:0065009
GO:0090080
GO:1901657
HGNC:15527
HPA021136
Hs.60380.0.A1_3p_at
Hs.90756.0.A1_3p_at
ILMN_1731688
IPR001360
IPR017853
KLB
KLB-201
MIM:611135
NM_175737
NP_783864
PF00232
PH_hs_0005057
PR00131
TC04000228.hg
uc003gua.4
UPI000000D726
Participant Of
input
FGFR4 binds HS:KLB:FGF19
hasComponent
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane]
FGFR4:HS:KLB:FGF19 [plasma membrane]
Inferred To
Homologues of KLB [plasma membrane] (Arabidopsis thaliana)
Homologues of KLB [plasma membrane] (Caenorhabditis elegans)
Homologues of KLB [plasma membrane] (Canis familiaris)
Homologues of KLB [plasma membrane] (Danio rerio)
Homologues of KLB [plasma membrane] (Oryza sativa)
KLB [plasma membrane] (Arabidopsis thaliana)
KLB [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Caenorhabditis elegans)
KLB [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Danio rerio)
KLB [plasma membrane] (Drosophila melanogaster)
KLB [plasma membrane] (Gallus gallus)
KLB [plasma membrane] (Mus musculus)
KLB [plasma membrane] (Oryza sativa)
KLB [plasma membrane] (Rattus norvegicus)
KLB [plasma membrane] (Sus scrofa)
KLB [plasma membrane] (Taeniopygia guttata)
KLB [plasma membrane] (Xenopus tropicalis)
Cross References
RefSeq
NP_783864.1
GeneCards
Q86Z14
PRO
Q86Z14
PDB
5VAQ
,
5VAN
,
5VAK
© 2018
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