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About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
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Userguide
Pathway Browser
How do I search ?
Details Panel
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Analysis Data
Analysis Gene Expression
Species Comparison
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Diseases
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Pathway Diagrams
Icon Info
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Citing us
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KLB [plasma membrane]
Stable Identifier
R-HSA-1307932
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
BetaKlotho
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4:pY-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR4 (Homo sapiens)
Downstream signaling of activated FGFR4 (Homo sapiens)
FRS-mediated FGFR4 signaling (Homo sapiens)
Activated FGFR4 binds FRS2 (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4 binds FRS3 (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4 phosphorylates FRS2 (Homo sapiens)
Activated FGFR4:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-8T-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4 phosphorylates FRS3 (Homo sapiens)
Activated FGFR4:FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4 phosphorylates PPTN11 (Homo sapiens)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS bind to PPTN11 (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS binds GRB2:SOS1 (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
PI-3K cascade:FGFR4 (Homo sapiens)
Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Phospholipase C-mediated cascade; FGFR4 (Homo sapiens)
Activated FGFR4 binds PLCG1 (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
activated FGFR4:PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4 phosphorylates PLCG1 (Homo sapiens)
activated FGFR4:PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
activated FGFR4:p-4Y-PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
p-4Y-PLCG1 dissociates from activated FGFR4 (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
activated FGFR4:p-4Y-PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
SHC-mediated cascade:FGFR4 (Homo sapiens)
Activated FGFR4 binds SHC1 (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4 phosphorylates SHC1 (Homo sapiens)
Activated FGFR4:SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:pY-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Homo sapiens)
Activated FGFR4:pY-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4:pY-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4:pY-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
FGFR4 ligand binding and activation (Homo sapiens)
betaKlotho-mediated ligand binding (Homo sapiens)
Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
FGFR4:HS:KLB:FGF19 [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
FGFR4 binds HS:KLB:FGF19 (Homo sapiens)
FGFR4:HS:KLB:FGF19 [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Negative regulation of FGFR4 signaling (Homo sapiens)
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Homo sapiens)
Activated FGFR4:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-8T-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
CBL ubiquitinates FRS2 and FGFR4 (Homo sapiens)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Ub-Activated FGFR4 complex:Ub-p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Homo sapiens)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
Activated FGFR bound to PI3K [cytosol] (Homo sapiens)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
IRS-related events triggered by IGF1R (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
Activated FGFR bound to PI3K [cytosol] (Homo sapiens)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86Z14 KLB
Gene Names
KLB
Chain
chain:1-1044
Reference Genes
BioGPS Gene:152831 KLB
COSMIC (genes):KLB KLB
CTD Gene:152831 KLB
dbSNP Gene:152831 KLB
ENSEMBL:ENSG00000134962 KLB
HGNC:15527 KLB
KEGG Gene (Homo sapiens):152831 KLB
Monarch:152831 KLB
NCBI Gene:152831 KLB
OMIM:611135 KLB
UCSC:Q86Z14 KLB
Reference Transcript
RefSeq:NM_175737.3 KLB
Other Identifiers
0002100546
11730624_at
11730625_at
11730626_at
152831
16966127
235708_at
244276_at
2724314
2724319
2724320
2724321
2724322
2724324
2724325
2724326
2724327
2724328
2724329
2724330
2724331
2724334
2724335
2724336
2724337
2724339
3604638
3605046
48338_at
53621_at
77001_at
8094679
A_23_P350617
A_23_P69531
A_32_P33114
GE574265
GO:0000165
GO:0003674
GO:0004553
GO:0005104
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005783
GO:0005886
GO:0005975
GO:0006464
GO:0007165
GO:0008150
GO:0008283
GO:0008284
GO:0008543
GO:0016020
GO:0016021
GO:0016798
GO:0017134
GO:0043226
GO:0051897
GO:0090080
Hs.60380.0.A1_3p_at
Hs.90756.0.A1_3p_at
ILMN_1731688
PH_hs_0005057
TC04000228.hg
Participant Of
input
FGFR4 binds HS:KLB:FGF19
hasComponent
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane]
FGFR4:HS:KLB:FGF19 [plasma membrane]
Inferred To
Homologues of KLB [plasma membrane] (Caenorhabditis elegans)
Dmel\CG9701 [plasma membrane] (Drosophila melanogaster)
Klb [plasma membrane] (Mus musculus)
klo-2 [plasma membrane] (Caenorhabditis elegans)
kl [plasma membrane] (Danio rerio)
kl [plasma membrane] (Xenopus tropicalis)
KLB [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Gallus gallus)
KLB [plasma membrane] (Sus scrofa)
klo-1 [plasma membrane] (Caenorhabditis elegans)
Cross References
RefSeq
NP_783864.1
OpenTargets
ENSG00000134962
GeneCards
Q86Z14
HPA
ENSG00000134962-KLB
Ensembl
ENSP00000257408
,
ENSG00000134962
,
ENST00000257408
PRO
Q86Z14
Orphanet
27042
PDB
5VAN
,
5VAK
,
5VAQ
,
6NFJ
,
5WI9
© 2021
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