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About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
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Citing us
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KLB [plasma membrane]
Stable Identifier
R-HSA-1307932
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
BetaKlotho
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
Activated FGFR bound to PI3K [cytosol] (Homo sapiens)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4:pY-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4:pY-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR4 (Homo sapiens)
Downstream signaling of activated FGFR4 (Homo sapiens)
FRS-mediated FGFR4 signaling (Homo sapiens)
Activated FGFR4 binds FRS2 (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4 binds FRS3 (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4 phosphorylates FRS2 (Homo sapiens)
Activated FGFR4:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-8T-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4 phosphorylates FRS3 (Homo sapiens)
Activated FGFR4:FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4 phosphorylates PPTN11 (Homo sapiens)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS bind to PPTN11 (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS binds GRB2:SOS1 (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
PI-3K cascade:FGFR4 (Homo sapiens)
Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Phospholipase C-mediated cascade; FGFR4 (Homo sapiens)
Activated FGFR4 binds PLCG1 (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
activated FGFR4:PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4 phosphorylates PLCG1 (Homo sapiens)
activated FGFR4:PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
activated FGFR4:p-4Y-PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
p-4Y-PLCG1 dissociates from activated FGFR4 (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
activated FGFR4:p-4Y-PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
SHC-mediated cascade:FGFR4 (Homo sapiens)
Activated FGFR4 binds SHC1 (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4 phosphorylates SHC1 (Homo sapiens)
Activated FGFR4:SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:pY-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Homo sapiens)
Activated FGFR4:pY-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4:pY-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR4:pY-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
FGFR4 ligand binding and activation (Homo sapiens)
betaKlotho-mediated ligand binding (Homo sapiens)
Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
FGFR4:HS:KLB:FGF19 [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
FGFR4 binds HS:KLB:FGF19 (Homo sapiens)
FGFR4:HS:KLB:FGF19 [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Negative regulation of FGFR4 signaling (Homo sapiens)
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Homo sapiens)
Activated FGFR4:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-8T-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
CBL ubiquitinates FRS2 and FGFR4 (Homo sapiens)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Ub-Activated FGFR4 complex:Ub-p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Homo sapiens)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR4 [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
Activated FGFR bound to PI3K [cytosol] (Homo sapiens)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
IRS-related events triggered by IGF1R (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
Activated FGFR bound to PI3K [cytosol] (Homo sapiens)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR [plasma membrane] (Homo sapiens)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Homo sapiens)
KLB [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86Z14 KLB
Gene Names
KLB
Chain
chain:1-1044
Reference Genes
BioGPS Gene:152831 KLB
COSMIC (genes):KLB KLB
CTD Gene:152831 KLB
dbSNP Gene:152831 KLB
ENSEMBL:ENSG00000134962 KLB
HGNC:15527 KLB
KEGG Gene (Homo sapiens):152831 KLB
Monarch:152831 KLB
NCBI Gene:152831 KLB
OMIM:611135 KLB
UCSC:Q86Z14 KLB
Reference Transcript
RefSeq:NM_175737.3 KLB
Other Identifiers
0002100546
11730624_at
11730625_at
11730626_at
152831
16966127
21136
235708_at
244276_at
2724314
2724319
2724320
2724321
2724322
2724324
2724325
2724326
2724327
2724328
2724329
2724330
2724331
2724334
2724335
2724336
2724337
2724339
3604638
3605046
48338_at
53621_at
5VAK
5VAN
5VAQ
5WI9
6NFJ
77001_at
8094679
A_23_P350617
A_23_P69531
A_32_P33114
AAI04872
AAI13654
AB079373
BAC56857
BC104871
BC113653
CCDS3451
ENSG00000134962
ENSP00000257408
ENST00000257408
ENST00000257408.4
EntrezGene:152831
EntrezGene:KLB
GE574265
GO:0000165
GO:0003674
GO:0004553
GO:0005104
GO:0005515
GO:0005575
GO:0005623
GO:0005886
GO:0005975
GO:0006464
GO:0007165
GO:0008150
GO:0008283
GO:0008284
GO:0008543
GO:0016020
GO:0016021
GO:0016798
GO:0017134
GO:0051897
GO:0090080
HGNC:15527
HPA021136
Hs.60380.0.A1_3p_at
Hs.90756.0.A1_3p_at
ILMN_1731688
IPR001360
IPR017853
KLB
KLB-201
MIM:611135
NM_175737
NP_783864
PF00232
PH_hs_0005057
PR00131
TC04000228.hg
UPI000000D726
Participant Of
input
FGFR4 binds HS:KLB:FGF19
hasComponent
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane]
FGFR4:HS:KLB:FGF19 [plasma membrane]
Inferred To
Homologues of KLB [plasma membrane] (Caenorhabditis elegans)
Ghost homologue of KLB [plasma membrane] (Rattus norvegicus)
KLB [plasma membrane] (Bos taurus)
KLB [plasma membrane] (Caenorhabditis elegans)
KLB [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Danio rerio)
KLB [plasma membrane] (Drosophila melanogaster)
KLB [plasma membrane] (Gallus gallus)
KLB [plasma membrane] (Mus musculus)
KLB [plasma membrane] (Sus scrofa)
KLB [plasma membrane] (Xenopus tropicalis)
Cross References
RefSeq
NP_783864.1
OpenTargets
ENSG00000134962
GeneCards
Q86Z14
PRO
Q86Z14
Orphanet
27042
PDB
6NFJ
,
5VAN
,
5VAQ
,
5WI9
,
5VAK
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