APAF1:CYCS binds APIP

Stable Identifier
R-HSA-6804596
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The APAF1 interacting protein (APIP) is an endogenous regulators of the apoptosome apparatus. APIP is thought to bind to the CARD domain of APAF1 preventing procaspase-9 recruitment to the apoptosome (Cho DH et al., 2004; Cao G et al., 2004; Kang W et al. 2014). Moreover, during hypoxic conditions, APIP may also induce sustained activation of AKT and ERK1/2 kinases, which directly phosphorylate procaspase-9 to inhibit its activation in the apoptosome (Cho DH et al., 2007).

Literature References
PubMed ID Title Journal Year
24367089 Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme

Kang, W, Hong, SH, Lee, HM, Kim, NY, Lim, YC, Le, le TM, Lim, B, Kim, HC, Kim, TY, Ashida, H, Yokota, A, Hah, SS, Chun, KH, Jung, YK, Yang, JK

Proc. Natl. Acad. Sci. U.S.A. 2014
Participants
Participant Of
Authored
Reviewed
Created