F9(29-461) N43Q [extracellular region]

Stable Identifier
R-HSA-9673228
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
factor IX propeptide N43Q
F9(29-461) N43Q [extracellular region] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
8295821 The Arg-4 mutant factor IX Strasbourg 2 shows a delayed activation by factor XIa

de la Salle, C, Charmantier, JL, Ravanat, C, Ohlmann, P, Hartmann, ML, Schuhler, S, Bischoff, R, Ebel, C, Roecklin, D, Balland, A

Nouv Rev Fr Hematol 1993
2738071 Factor IX San Dimas. Substitution of glutamine for Arg-4 in the propeptide leads to incomplete gamma-carboxylation and altered phospholipid binding properties.

Ware, J, Diuguid, DL, Liebman, HA, Rabiet, MJ, Kasper, CK, Furie, BC, Furie, B, Stafford, DW

J Biol Chem 1989
9169594 Modification of the N-terminus of human factor IX by defective propeptide cleavage or acetylation results in a destabilized calcium-induced conformation: effects on phospholipid binding and activation by factor XIa

Wojcik, EG, Van Den Berg, M, Poort, SR, Bertina, RM

Biochem. J. 1997
2788012 Defective propeptide processing and abnormal activation underlie the molecular pathology of factor IX Troed-y-Rhiw

Liddell, MB, Lillicrap, DP, Peake, IR, Bloom, AL

Br. J. Haematol. 1989
External Reference Information
External Reference
Gene Names
F9
Chain
signal peptide:1-28, propeptide:29-46, chain:47-461, chain:47-191, propeptide:192-226, chain:227-461
Other Identifiers
0001090301
11735185_a_at
11735186_a_at
11735187_at
11745643_a_at
17107373
207218_at
2158
35556_at
3993078
3993079
3993081
3993082
3993084
3993085
3993086
3993090
3993091
3993092
3993093
3993094
3993095
3993097
3993098
8170215
A_14_P113911
A_14_P200623
A_23_P62406
A_33_P3390411
GE80895
GO:0003674
GO:0004175
GO:0004252
GO:0005509
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005783
GO:0005788
GO:0005794
GO:0005796
GO:0005886
GO:0006508
GO:0006810
GO:0006888
GO:0006950
GO:0007596
GO:0007597
GO:0007599
GO:0008150
GO:0008233
GO:0008236
GO:0016192
GO:0016787
GO:0031012
GO:0031638
GO:0043167
GO:0043226
GO:0046872
GO:0051604
GO:0062023
GO:0070062
ILMN_1787598
ILMN_1810651
K02402_at
PH_hs_0000181
TC0X000676.hg
g10518507_3p_at
Participant Of
Other forms of this molecule
Modified Residues
Name
L-arginine 43 replaced with L-glutamine
Coordinate
43
PsiMod
A protein modification that effectively converts a source amino acid residue to an L-glutamine.
A protein modification that effectively removes or replaces an L-arginine.
Disease
Name Identifier Synonyms
hemophilia B 12259 factor IX deficiency, Congenital factor IX deficiency, deficiency, functional factor IX, Congenital factor IX disorder
Cross References
OpenTargets
ZINC - Substances
ZINC target
PRO
ZINC - Investigational
GeneCards
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (2)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q3U4G3 XXLT1      0.618 3
 UniProt:P00451-PRO_0000002968 F8      0.544 2
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