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CCL20(27-96) [extracellular region]
Stable Identifier
R-HSA-373097
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
CCL20, C-C motif chemokine 20, CCL20_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-10 signaling (Homo sapiens)
IL10 negatively regulates extracellular inflammatory mediators (Homo sapiens)
IL10-downregulated extracellular proteins [extracellular region] (Homo sapiens)
CCL20(27-96) [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR6:CCL20 [plasma membrane] (Homo sapiens)
CCL20(27-96) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR6:CCL20 [plasma membrane] (Homo sapiens)
CCL20(27-96) [extracellular region] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR6:CCL20 [plasma membrane] (Homo sapiens)
CCL20(27-96) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR6:CCL20 [plasma membrane] (Homo sapiens)
CCL20(27-96) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR6:CCL20 [plasma membrane] (Homo sapiens)
CCL20(27-96) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR6:CCL20 [plasma membrane] (Homo sapiens)
CCL20(27-96) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Chemokine receptors bind chemokines (Homo sapiens)
Receptor CCR6 binds CCL20 ligand (Homo sapiens)
CCL20(27-96) [extracellular region] (Homo sapiens)
CCR6:CCL20 [plasma membrane] (Homo sapiens)
CCL20(27-96) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P78556 CCL20
Gene Names
CCL20, LARC, MIP3A, SCYA20
Chain
signal peptide:1-26, chain:27-96, chain:27-93, chain:27-90, chain:28-96
Reference Genes
BioGPS Gene:6364 CCL20
COSMIC (genes):CCL20 CCL20
CTD Gene:6364 CCL20
dbSNP Gene:6364 CCL20
ENSEMBL:ENSG00000115009 CCL20
ENSEMBL_homo_sapiens_GENE:ENSG00000115009.13 CCL20
HGNC:10619 CCL20
KEGG Gene (Homo sapiens):6364 CCL20
Monarch:6364 CCL20
NCBI Gene:6364 CCL20
OMIM:601960 CCL20
UCSC:P78556 CCL20
Reference Transcript
RefSeq:NM_001130046.1 CCL20
RefSeq:NM_004591.2 CCL20
Other Identifiers
11724828_at
16891774
205476_PM_at
205476_at
2530714
2530715
2530717
2530718
2530719
2530722
2530723
40385_at
6364
8048864
A_23_P17065
GE79000
GO:0002376
GO:0002548
GO:0005125
GO:0005515
GO:0005576
GO:0005615
GO:0006935
GO:0006954
GO:0006955
GO:0007165
GO:0007186
GO:0007267
GO:0008009
GO:0016477
GO:0023052
GO:0030593
GO:0031731
GO:0035584
GO:0042379
GO:0042742
GO:0048018
GO:0048020
GO:0048247
GO:0048870
GO:0060326
GO:0070098
GO:0070374
GO:0071346
GO:0071347
GO:0071356
GO:0072678
GO:0072679
GO:0098542
GO:0098772
GO:2000406
HMNXSV003053529
ILMN_1657234
PH_hs_0004333
TC02001364.hg
U64197_at
g4759075_3p_at
Participates
as a member of
IL10-downregulated extracellular proteins [extracellular region] (Homo sapiens)
as an input of
Receptor CCR6 binds CCL20 ligand (Homo sapiens)
as a component of
CCR6:CCL20 [plasma membrane] (Homo sapiens)
Inferred To
Ccl20 [extracellular region]
(Mus musculus)
Ccl20 [extracellular region]
(Rattus norvegicus)
MIP-3alpha [extracellular region]
(Gallus gallus)
CCL20 [extracellular region]
(Bos taurus)
CCL20 [extracellular region]
(Sus scrofa)
Cross References
RefSeq
NP_001123518.1
,
NP_004582.1
OpenTargets
ENSG00000115009
GeneCards
P78556
HPA
ENSG00000115009-CCL20
Ensembl
ENSP00000351671
,
ENSP00000386273
,
ENST00000358813
,
ENST00000409189
,
ENSG00000115009
PRO
P78556
Pharos - Targets
P78556
PDB
2HCI
,
7T1E
,
5UR7
,
1M8A
,
6WWZ
,
2JYO
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15311 RALBP1
1
RALBP1 [cytosol]
(R-HSA-195194)
0.589
2
UniProt:P02776 PF4
4
PF4(32-101) [platelet alpha granule lumen]
(R-HSA-114652)
PF4(48-101) [platelet alpha granule lumen]
(R-HSA-114628)
PF4(32-101) [extracellular region]
(R-HSA-61823)
PF4(48-101) [extracellular region]
(R-HSA-114629)
0.558
2
UniProt:P48061 CXCL12
1
CXCL12(22-93) [extracellular region]
(R-HSA-2980693)
0.558
2
UniProt:P13501 CCL5
1
CCL5(24-91) [extracellular region]
(R-HSA-373108)
0.558
2
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