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G-protein alpha (q/11): GTP [plasma membrane]
Stable Identifier
R-HSA-114534
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Signal amplification (Homo sapiens)
ADP signalling through P2Y purinoceptor 1 (Homo sapiens)
Dissociation of the P2Y purinoceptor 1:Gq complex (Homo sapiens)
ADP:P2RY1:G-protein Gq (active) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
Gq activation by P2Y purinoceptor 1 (Homo sapiens)
ADP:P2RY1:G-protein Gq (active) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
P2Y purinoceptor 1 activates MAP kinase p38 alpha (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
Thromboxane signalling through TP receptor (Homo sapiens)
Dissociation of the TP:Gq complex (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
TP receptor:Thromboxane A2:G-protein Gq (active) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
Gq activation by TP receptor (Homo sapiens)
TP receptor:Thromboxane A2:G-protein Gq (active) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
Thrombin signalling through proteinase activated receptors (PARs) (Homo sapiens)
Thrombin-activated PARs activate Gq (Homo sapiens)
Thrombin-activated PAR:Gq (active) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
Thrombin-activated PARs:Gq (active) dissociate (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
Thrombin-activated PAR:Gq (active) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Active G alpha (q) binds RGS proteins (Homo sapiens)
G alpha (q):GTP:RGS [plasma membrane] (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
Active Gq binds BTK (Homo sapiens)
Active Gq:BTK [plasma membrane] (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
BTK in active Gq-BTK complex is activated (Homo sapiens)
Active Gq:Active BTK [plasma membrane] (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
Active Gq:BTK [plasma membrane] (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
G alpha (q) binds to Trio family RhoGEFs (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
G-protein alpha (q/11):Trio family RhoGEFs [plasma membrane] (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
G alpha (q) in G (q):RGS complex is inactivated (Homo sapiens)
G alpha (q):GTP:RGS [plasma membrane] (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
G alpha (q) inhibits PI3K alpha (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
G-protein alpha (q/11):PI3K alpha [plasma membrane] (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
GRK2 sequesters activated Gq (Homo sapiens)
G-protein alpha (q):GRK2 [plasma membrane] (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
GRK5 sequesters activated Gq (Homo sapiens)
G-protein alpha (q):GRK5 [plasma membrane] (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
Gq-BTK complex dissociates to Active BTK and Gq (Homo sapiens)
Active Gq:Active BTK [plasma membrane] (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
PLC beta is activated by G alpha (q) (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
PLC beta:G alpha (q/11) [plasma membrane] (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
PLC-beta hydrolyses PIP2 to DAG and IP3 (Homo sapiens)
PLC beta:G alpha (q/11) [plasma membrane] (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane] (Homo sapiens)
PLC beta:G alpha (q/11) [plasma membrane] (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Homo sapiens)
PLC beta:G alpha (q/11) [plasma membrane] (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
Participants
components
G-protein alpha (q/11/14/15) [plasma membrane]
(Homo sapiens)
GTP [cytosol]
Participates
as an output of
Gq-BTK complex dissociates to Active BTK and Gq (Homo sapiens)
Dissociation of the TP:Gq complex (Homo sapiens)
Thrombin-activated PARs:Gq (active) dissociate (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Dissociation of the P2Y purinoceptor 1:Gq complex (Homo sapiens)
as a component of
G-protein alpha (q):GRK5 [plasma membrane] (Homo sapiens)
Active Gq:Active BTK [plasma membrane] (Homo sapiens)
Active Gq:BTK [plasma membrane] (Homo sapiens)
G-protein alpha (q/11):Trio family RhoGEFs [plasma membrane] (Homo sapiens)
G-protein alpha (q):GRK2 [plasma membrane] (Homo sapiens)
G alpha (q):GTP:RGS [plasma membrane] (Homo sapiens)
G-protein alpha (q/11):PI3K alpha [plasma membrane] (Homo sapiens)
PLC beta:G alpha (q/11) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
as an input of
GRK5 sequesters activated Gq (Homo sapiens)
Active Gq binds BTK (Homo sapiens)
G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)
G alpha (q) binds to Trio family RhoGEFs (Homo sapiens)
PLC beta is activated by G alpha (q) (Homo sapiens)
GRK2 sequesters activated Gq (Homo sapiens)
Active G alpha (q) binds RGS proteins (Homo sapiens)
G alpha (q) inhibits PI3K alpha (Homo sapiens)
Inferred To
G protein alpha:GTP complex [plasma membrane]
(Bos taurus)
G protein alpha:GTP complex [plasma membrane]
(Caenorhabditis elegans)
G protein alpha:GTP complex [plasma membrane]
(Canis familiaris)
G protein alpha:GTP complex [plasma membrane]
(Dictyostelium discoideum)
G protein alpha:GTP complex [plasma membrane]
(Drosophila melanogaster)
G protein alpha:GTP complex [plasma membrane]
(Gallus gallus)
G protein alpha:GTP complex [plasma membrane]
(Mus musculus)
G protein alpha:GTP complex [plasma membrane]
(Rattus norvegicus)
G protein alpha:GTP complex [plasma membrane]
(Saccharomyces cerevisiae)
G protein alpha:GTP complex [plasma membrane]
(Schizosaccharomyces pombe)
G protein alpha:GTP complex [plasma membrane]
(Sus scrofa)
G protein alpha:GTP complex [plasma membrane]
(Xenopus tropicalis)
G-protein alpha (q/11): GTP [plasma membrane]
(Danio rerio)
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