GRK5 sequesters activated Gq

Stable Identifier
R-HSA-416510
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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GRK5 sequesters activated Gq
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GRKs are serine/threonine kinases that phosphorylate GPCRs leading to receptor desensitization. GRK5 appears to be the predominant regulator of PAR1 desensitization in endothelial cells.

Literature References
PubMed ID Title Journal Year
10861009 G protein-coupled receptor kinase-5 regulates thrombin-activated signaling in endothelial cells

Pronin, AN, Tiruppathi, C, Malik, AB, Yan, W, Naqvi, T, Benovic, JL, Sandoval, R

Proc Natl Acad Sci U S A 2000
Participants
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Inferred From
GRK2 sequesters activated Gq (Homo sapiens)
Authored
Jupe, S  (2009-03-27)
Reviewed
Akkerman, JW  (2009-06-03)
Created
Jupe, S  (2009-03-27)
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