Reactome | Active Gq binds BTK

Active Gq binds BTK

Stable Identifier

R-HSA-8964280

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins. Upon activation, the Guanine nucleotide-binding protein G(q) subunit alpha class (GNAQ/GNA11/GNA14/GNA15) can bind directly to the THSH3 domain of the non-receptor Tyrosine-protein kinase BTK in vitro and in vivo. This binding results in a conformational change in BTK, which leads to its activation. Physiologically, BTK plays a key role in B lymphocyte development, differentiation and signalling.

Literature References

PubMed ID	Title	Journal	Year
9770463	Identification of the binding site for Gqalpha on its effector Bruton's tyrosine kinase Huang, XY, Ma, YC	Proc. Natl. Acad. Sci. U.S.A.	1998
9305846	Direct stimulation of Bruton's tyrosine kinase by G(q)-protein alpha-subunit Kozasa, T, Ma, W, Huang, XY, Bence, K	Nature	1997
11742120	Competing modes of self-association in the regulatory domains of Bruton's tyrosine kinase: intramolecular contact versus asymmetric homodimerization Huang, XY, Fulton, DB, Andreotti, AH, Laederach, A, Brazin, KN, Zamoon, J, Cradic, KW	Protein Sci.	2002