Active Gq binds BTK

Stable Identifier
Reaction [binding]
Homo sapiens
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G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins. Upon activation, the Guanine nucleotide-binding protein G(q) subunit alpha class (GNAQ/GNA11/GNA14/GNA15) can bind directly to the THSH3 domain of the non-receptor Tyrosine-protein kinase BTK in vitro and in vivo. This binding results in a conformational change in BTK, which leads to its activation. Physiologically, BTK plays a key role in B lymphocyte development, differentiation and signalling.

Literature References
PubMed ID Title Journal Year
9770463 Identification of the binding site for Gqalpha on its effector Bruton's tyrosine kinase

Huang, XY, Ma, YC

Proc. Natl. Acad. Sci. U.S.A. 1998
9305846 Direct stimulation of Bruton's tyrosine kinase by G(q)-protein alpha-subunit

Kozasa, T, Ma, W, Huang, XY, Bence, K

Nature 1997
11742120 Competing modes of self-association in the regulatory domains of Bruton's tyrosine kinase: intramolecular contact versus asymmetric homodimerization

Huang, XY, Fulton, DB, Andreotti, AH, Laederach, A, Brazin, KN, Zamoon, J, Cradic, KW

Protein Sci. 2002
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