Reactome | G alpha (q) inhibits PI3K alpha

G alpha (q) inhibits PI3K alpha

Stable Identifier

R-HSA-416358

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Phospholipase C activation is the classical signalling route for G alpha (q) but an additional mechanism is an inhibitory interaction between G alpha (q) and phosphatidylinositol 3-kinase alpha (PI3K alpha). There are several PI3K subtypes but only the p85 alpha/p110 alpha subtype (PI3K alpha) is a G alpha (q) effector (PMID: 18515384). Activated G alpha (q) inhibits PI3K alpha directly, in a GTP-dependent manner. G alpha(q) binding of PI3K competes with Ras, a PI3K activator (PMID: 16268778).

Literature References

PubMed ID	Title	Journal	Year
18515384	Galphaq binds two effectors separately in cells: evidence for predetermined signaling pathways Golebiewska, U, Scarlata, S	Biophys J	2008
16268778	Galphaq binds to p110alpha/p85alpha phosphoinositide 3-kinase and displaces Ras Ballou, LM, Chattopadhyay, M, Li, Y, Scarlata, S, Lin, RZ	Biochem J	2006