Expression of IFN-induced genes

Stable Identifier
R-HSA-1015702
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Around 300 IFN-induced genes have been identified from different oligonucleotide microarray studies in melanoma (WM9) and fibrosarcoma (HT1080) cell lines as well as from human dendritic cells treated with IFN. Only the proteins which are well studied and their function characterized are represented here.

Literature References
PubMed ID Title Journal Year
14769151 Novel growth and death related interferon-stimulated genes (ISGs) in melanoma: greater potency of IFN-beta compared with IFN-alpha2

Leaman, DW, Chawla-Sarkar, M, Jacobs, B, Vyas, K, Sun, Y, Ozdemir, A, Yi, T, Williams, BR, Borden, EC

J Interferon Cytokine Res 2003
9861020 Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays

Der, SD, Zhou, A, Williams, BR, Silverman, RH

Proc Natl Acad Sci U S A 1998
6548414 Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells

Friedman, RL, Manly, SP, McMahon, M, Kerr, IM, Stark, GR

Cell 1984
1730654 Regulation of the Egr-1 gene by tumor necrosis factor and interferons in primary human fibroblasts

Cao, XM, Guy, GR, Sukhatme, VP, Tan, YH

J Biol Chem 1992
12029096 Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis

Leaman, DW, Chawla-Sarkar, M, Vyas, K, Reheman, M, Tamai, K, Toji, S, Borden, EC

J Biol Chem 2002
11337497 Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cells

Morrison, BH, Bauer, JA, Kalvakolanu, DV, Lindner, DJ

J Biol Chem 2001
11092454 Gene structure and function of the 2'-5'-oligoadenylate synthetase family

Justesen, J, Hartmann, R, Kjeldgaard, NO

Cell Mol Life Sci 2000
11404376 Functional classification of interferon-stimulated genes identified using microarrays

de Veer, MJ, Holko, M, Frevel, M, Walker, E, Der, S, Paranjape, JM, Silverman, RH, Williams, BR

J Leukoc Biol 2001
2211721 Differential expression and distinct structure of 69- and 100-kDa forms of 2-5A synthetase in human cells treated with interferon

MariƩ, I, Svab, J, Robert, N, Galabru, J, Hovanessian, AG

J Biol Chem 1990
6162102 Interferon action--sequence specificity of the ppp(A2'p)nA-dependent ribonuclease

Wreschner, DH, McCauley, JW, Skehel, JJ, Kerr, IM

Nature 1981
16009940 Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways

Zhao, C, Denison, C, Huibregtse, JM, Gygi, S, Krug, RM

Proc Natl Acad Sci U S A 2005
9096384 A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis

Der, SD, Yang, YL, Weissmann, C, Williams, BR

Proc Natl Acad Sci U S A 1997
15047845 Human MxA protein inhibits the replication of Crimean-Congo hemorrhagic fever virus

Andersson, I, Bladh, L, Mousavi-Jazi, M, Magnusson, KE, Lundkvist, A, Haller, O, Mirazimi, A

J Virol 2004
Participants
Participant Of
This event is regulated
Authored
Reviewed
Created