Reactome | IFIT1 [cytosol]

IFIT1 [cytosol]

Stable Identifier

R-HSA-937341

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Interferon-induced protein with tetratricopeptide repeats 1, IFIT1_HUMAN

Icon

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P09914 IFIT1

Gene Names

IFIT1, G10P1, IFI56, IFNAI1, ISG56

Chain

chain:1-478

Reference Genes

BioGPS Gene:3434 IFIT1

COSMIC (genes):IFIT1 IFIT1

CTD Gene:3434 IFIT1

dbSNP Gene:3434 IFIT1

ENSEMBL:ENSG00000185745 IFIT1

ENSEMBL_homo_sapiens_GENE:ENSG00000185745.10 IFIT1

HGNC:5407 IFIT1

KEGG Gene (Homo sapiens):3434 IFIT1

Monarch:3434 IFIT1

NCBI Gene:3434 IFIT1

OMIM:147690 IFIT1

UCSC:P09914 IFIT1

Reference Transcript

Other Identifiers

11756820_a_at

16707196

203153_PM_at

203153_at

3257244

3257247

3257250

3257251

3257252

3257253

3257254

3257255

3257256

3257257

3257258

3257259

3257263

3257265

32814_at

3434

7929065

915_at

A_23_P52266

GE59650

GO:0002376

GO:0003723

GO:0005515

GO:0005737

GO:0005829

GO:0009615

GO:0019060

GO:0032091

GO:0043657

GO:0045070

GO:0045071

GO:0045087

GO:0051097

GO:0051607

GO:0051707

GO:0071357

GO:0071360

GO:0098542

GO:0140374

HMNXSV003023209

ILMN_1707695

M24594_at

PH_hs_0001767

TC10000639.hg

g4504584_3p_at

Participates

as a member of

ISG15 targets [cytosol] (Homo sapiens)

as an output of

Expression of IFN-induced genes (Homo sapiens)

Inferred To

IFIT1 [cytosol] (Bos taurus)

Ifit1bl [cytosol] (Rattus norvegicus)

Ifit1bl2 [cytosol] (Mus musculus)

LOC488947 [cytosol] (Canis familiaris)

IFIT3 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001539.3, NP_001257859.1, NP_001257857.1, NP_001257858.1

OpenTargets

ENSG00000185745

GeneCards

P09914

HPA

ENSG00000185745-IFIT1

Ensembl

ENSP00000441968, ENST00000371804, ENST00000546318, ENSP00000360869, ENSG00000185745

PRO

P09914

Pharos - Targets

P09914

PDB

5UDI, 6C6K, 5W5I, 4HOU, 5UDK, 5W5H, 5UDL, 5UDJ

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14879 IFIT3	1	IFIT3 [cytosol] (R-HSA-947491)	0.915	12
UniProt:P09913 IFIT2	1	IFIT2 [cytosol] (R-HSA-1015674)	0.748	7
UniProt:P06789 VE1			0.645	8
UniProt:Q86WV6 STING1	5	TMEM173 [plasma membrane] (R-HSA-6804815) TMEM173 [secretory granule membrane] (R-HSA-6804798) K63polyUb-STING [endoplasmic reticulum membrane] (R-HSA-3134805) K63polyUb-STING [cytoplasmic vesicle membrane] (R-HSA-3248021) STING [endoplasmic reticulum membrane] (R-HSA-1834940)	0.558	3
UniProt:P01566 IFNA10	1	IFNA10 [extracellular region] (R-HSA-877339)	0.527	2
UniProt:P01568 IFNA21	1	IFNA21 [extracellular region] (R-HSA-877343)	0.527	2
UniProt:P01569 IFNA5	1	IFNA5 [extracellular region] (R-HSA-877338)	0.527	2
UniProt:P01570 IFNA14	1	IFNA14 [extracellular region] (R-HSA-877345)	0.527	3
UniProt:P32881 IFNA8	1	IFNA8 [extracellular region] (R-HSA-877336)	0.527	2