pyruvate + NADH + H+ <=> lactate + NAD+

Stable Identifier
Reaction [transition]
Gallus gallus
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Cytosolic lactate dehydrogenase catalyzes the reversible reaction of pyruvate and NADH + H+ to form lactate and NAD+. There are two isoforms of lactate dehydrogenase encoded by two different genes whose expression levels vary from tissue to tissue and as a function of developmental stage. The active form of the enzyme is a tetramer, whose composition in a tissue appears to be determined by the relative abundances of the two monomer isoforms. All five possible lactate dehydrogenase isoforms have been described; no functional differences among them have been found (Lindsay 1963; Hirota et al. 1990).

Literature References
PubMed ID Title Journal Year
2243792 Nucleotide and deduced amino acid sequences of chicken lactate dehydrogenase-A

Hirota, Y, Katsumata, A, Takeya, T

Nucl Acids Res 1990
13930828 Isozymic patterns and properties of lactate dehydrogenase from developing tissues of the chicken

Lindsay, DT

J Exp Zool 1963
Event Information
Catalyst Activity

L-lactate dehydrogenase activity of LDH tetramer isoforms [cytosol]

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