Pyruvate metabolism

Stable Identifier
R-GGA-373920
Type
Pathway
Species
Gallus gallus
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Pyruvate sits at an intersection of key pathways of energy metabolism. It is the end product of glycolysis and the starting point for gluconeogenesis IWatford 1985). It can be converted by the pyruvate dehydrogenase complex to acetyl CoA which can enter the TCA cycle or serve as the starting point for the syntheses of long chain fatty acids, steroids, and ketone bodies. It also plays a central role in balancing the energy needs of various tissues in the body: under anaerobic conditions (e.g., rapidly exercising white muscle), pyruvate is reduced to lactate which is exported from the cell and taken up by tissues that can re-oxidize it to pyruvate for futher oxidative metabolism via acetyl CoA (e.g., red muscle) or for gluconeogenesis (e.g., kidney cortex) (Wilson et al. 1998; Yorita et al. 1987).

Literature References
PubMed ID Title Journal Year
3688272 Distribution of glycolysis and gluconeogenesis in perfused chicken kidney

Yorita, K, Yamano, T, Ikeda, K, Kobayashi, T, Shiota, M, Sugano, T

Am J Physiol 1987
9632638 Lactic acid efflux from white skeletal muscle is catalyzed by the monocarboxylate transporter isoform MCT3

Wilson, MC, Jackson, VN, Heddle, C, Price, NT, Pilegaard, H, Juel, C, Bonen, A, Montgomery, I, Hutter, OF, Halestrap, AP

J Biol Chem 1998
2985455 Gluconeogenesis in the chicken: regulation of phosphoenolpyruvate carboxykinase gene expression

Watford, M

Fed Proc 1985
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