lactate + NAD+ <=> pyruvate + NADH + H+

Stable Identifier
R-GGA-372903
Type
Reaction [transition]
Species
Gallus gallus
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic lactate dehydrogenase catalyzes the reversible reaction of lactate and NAD+ to form pyruvate and NADH + H+. There are two isoforms of lactate dehydrogenase encoded by two different genes whose expression levels vary from tissue to tissue and as a function of developmental stage. The active form of the enzyme is a tetramer, whose composition in a tissue appears to be determined by the relative abundances of the two monomer isoforms. All five possible lactate dehydrogenase isoforms have been described; no functional differences among them have been found (Lindsay 1963; Hirota et al. 1990).

Literature References
PubMed ID Title Journal Year
2243792 Nucleotide and deduced amino acid sequences of chicken lactate dehydrogenase-A

Hirota, Y, Katsumata, A, Takeya, T

Nucl Acids Res 1990
13930828 Isozymic patterns and properties of lactate dehydrogenase from developing tissues of the chicken

Lindsay, DT

J Exp Zool 1963
Participants
Participates
Catalyst Activity

L-lactate dehydrogenase activity of LDH tetramer isoforms [cytosol]

Authored
Created
Cite Us!