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MAPK1 [cytosol]
Stable Identifier
R-DME-59282
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
P40417
Locations in the PathwayBrowser
Expand all
Developmental Biology (Drosophila melanogaster)
Nervous system development (Drosophila melanogaster)
Axon guidance (Drosophila melanogaster)
L1CAM interactions (Drosophila melanogaster)
Signal transduction by L1 (Drosophila melanogaster)
MAP2K2 phosphorylates MAPK1 (Drosophila melanogaster)
p-S,T-MAP2K2:MAPK1 [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
Hemostasis (Drosophila melanogaster)
Platelet activation, signaling and aggregation (Drosophila melanogaster)
Thrombin signalling through proteinase activated receptors (PARs) (Drosophila melanogaster)
Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Drosophila melanogaster)
F2R:ARRB1:MAPKs:SRC-1 [plasma membrane] (Drosophila melanogaster)
MAPKs [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
SRC-1 bound to ARRB2 is not activated (Drosophila melanogaster)
F2R:ARRB2:MAPKs:SRC-1 [plasma membrane] (Drosophila melanogaster)
MAPKs [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Drosophila melanogaster)
F2R:ARRB1:MAPKs:SRC-1 [plasma membrane] (Drosophila melanogaster)
MAPKs [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF-independent MAPK1/3 activation (Drosophila melanogaster)
Cytosolic DUSPs dephosphorylate MAPKs (Drosophila melanogaster)
MAPK monomers and dimers [cytosol] (Drosophila melanogaster)
MAPK1 dimer [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
MAPKs [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
MAPK1 (ERK2) activation (Drosophila melanogaster)
MAP2K2 binds MAPK1 (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
p-S,T-MAP2K2:MAPK1 [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
MAP2K2 phosphorylates MAPK1 (Drosophila melanogaster)
p-S,T-MAP2K2:MAPK1 [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
MAP2K and MAPK activation (Drosophila melanogaster)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
MAPKs [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
MAPKs [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
Dual mechanism MAPK inhibitors bind MAPKs (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
MAPKs [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
MAPKs [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Drosophila melanogaster)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Drosophila melanogaster)
MAPKs [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
MAP2Ks and MAPKs bind to the activated RAF complex (Drosophila melanogaster)
MAPKs [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
MAPKs [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
MAP2Ks phosphorylate MAPK at the Golgi membrane (Drosophila melanogaster)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Drosophila melanogaster)
MAPKs [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
MAP2Ks phosphorylate MAPKs (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
MAPKs [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
MAPKs [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
MAPKs [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
MAPKs [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
RAF phosphorylates MAP2K dimer (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
MAPKs [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
MAPKs [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
MAPKs [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
MAPKs [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
MAPKs [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Drosophila melanogaster)
MAPKs [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Drosophila melanogaster)
MAPKs [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
Negative regulation of MAPK pathway (Drosophila melanogaster)
Cytosolic DUSPs dephosphorylate MAPKs (Drosophila melanogaster)
MAPK monomers and dimers [cytosol] (Drosophila melanogaster)
MAPK1 dimer [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
MAPKs [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by Insulin receptor (Drosophila melanogaster)
Insulin receptor signalling cascade (Drosophila melanogaster)
Signal attenuation (Drosophila melanogaster)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Drosophila melanogaster)
MAPK3,(MAPK1) [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Drosophila melanogaster)
MAPK3,(MAPK1) [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
Signaling by NTRKs (Drosophila melanogaster)
Signaling by NTRK1 (TRKA) (Drosophila melanogaster)
Signalling to ERKs (Drosophila melanogaster)
Prolonged ERK activation events (Drosophila melanogaster)
Frs2-mediated activation (Drosophila melanogaster)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Drosophila melanogaster)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Drosophila melanogaster)
MAPKs [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Drosophila melanogaster)
MAPKs [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Drosophila melanogaster)
MAPKs [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Drosophila melanogaster)
MAPKs [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Drosophila melanogaster)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Drosophila melanogaster)
MAPKs [cytosol] (Drosophila melanogaster)
MAPK1 [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P40417
Reference Genes
BioGPS Gene:3354888
CTD Gene:3354888
ENSEMBL:FBgn0003256
Flybase:FBgn0003256
KEGG Gene (Drosophila melanogaster):Dmel_CG12559
Monarch:3354888
NCBI Gene:3354888
Reference Transcript
RefSeq:NM_001110879.2
RefSeq:NM_001015121.3
RefSeq:NM_001110878.4
RefSeq:NM_001015123.3
RefSeq:NM_001015122.3
RefSeq:NM_001300706.2
Other Identifiers
1629549_s_at
3354888
GO:0000165
GO:0000166
GO:0000278
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004707
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006468
GO:0006914
GO:0007049
GO:0007166
GO:0007173
GO:0007362
GO:0007430
GO:0007465
GO:0007474
GO:0007476
GO:0007479
GO:0007552
GO:0008284
GO:0008286
GO:0008293
GO:0008340
GO:0008543
GO:0009267
GO:0009605
GO:0016242
GO:0016301
GO:0016310
GO:0016740
GO:0019901
GO:0022414
GO:0023052
GO:0030154
GO:0031594
GO:0033554
GO:0034614
GO:0035169
GO:0035170
GO:0035202
GO:0035556
GO:0036211
GO:0042060
GO:0043226
GO:0045500
GO:0045793
GO:0046534
GO:0046843
GO:0048010
GO:0048149
GO:0048856
GO:0050804
GO:0051091
GO:0051607
GO:0060446
GO:0070371
GO:0071243
GO:0071276
GO:0090303
GO:0098542
GO:0106310
GO:0140096
GO:0140297
GO:2000826
GO:2001023
Participates
as a candidate of
MAPK3,(MAPK1) [cytosol] (Drosophila melanogaster)
as a component of
MAPK1 dimer [cytosol] (Drosophila melanogaster)
p-S,T-MAP2K2:MAPK1 [cytosol] (Drosophila melanogaster)
as an input of
MAP2K2 binds MAPK1 (Drosophila melanogaster)
as a member of
MAPKs [cytosol] (Drosophila melanogaster)
Other forms of this molecule
phospho-p-T185,Y187-MAPK1 [nucleoplasm]
phospho-p-T202,Y204-MAPK3 [nucleoplasm]
phospho-p-T202,Y204-MAPK3 [cytosol]
phospho-p-T185,Y187-MAPK1 [cytosol]
MAPK3 [cytosol]
MAPK3 [nucleoplasm]
MAPK1 [nucleoplasm]
phospho-p-T185-MAPK1 [cytosol]
phospho-p-T202-MAPK3 [cytosol]
phospho-p-Y204-MAPK3-3 [cytosol]
MAPK1 [ficolin-1-rich granule lumen]
MAPK1 [extracellular region]
MAPK1 [azurophil granule lumen]
Inferred From
MAPK1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001104348.2
,
NP_001015122.1
,
NP_001104349.1
,
NP_001015121.3
,
NP_001015123.1
,
NP_001287635.1
Flybase
FBgn0003256
IntEnz
2.7.11.24
PRO
P40417
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9U1H0 CIC
0.593
3
UniProt:Q24106 HID
0.59
3
UniProt:Q9V393 krz
8
krz [cytoplasmic vesicle membrane]
(R-DME-351187-3)
krz [Golgi membrane]
(R-DME-350831-3)
krz [lysosomal membrane]
(R-DME-432701-3)
krz [cytosol]
(R-DME-6783000)
krz [cytosol]
(R-DME-6783186-3)
Krz [cytosol]
(R-DME-2071841)
krz [cytosol]
(R-DME-416464)
krz [cytosol]
(R-DME-264470-3)
0.544
12
UniProt:Q24324 Dsor1
9
DSOR1 [cytosol]
(R-DME-205968)
phospho-p-S,218, S222,T292 MAP2K1 [cytosol]
(R-DME-5674490)
phospho-p-S,T-MAP2K2 [cytosol]
(R-DME-109848)
phospho-p-T286,T292-MAP2K1 [cytosol]
(R-DME-112374)
phospho-p-S218,S222,T286,T292-MAP2K1 [cytosol]
(R-DME-112339)
MAP2K1 [cytosol]
(R-DME-59502)
MAP2K2 [cytosol]
(R-DME-59504)
phospho-p-S222,S226-MAP2K2 [cytosol]
(R-DME-169292)
phospho-p-S218,S222-MAP2K1 [cytosol]
(R-DME-109837)
0.534
2
UniProt:Q24496 Q24496
0.524
2
UniProt:Q9W2K3 Q9W2K3
0.488
2
UniProt:P21461
2
SIAH2 [cytosol]
(R-DME-374566)
SIAH1 [cytosol]
(R-DME-374563)
0.488
2
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