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rl [cytosol]
Stable Identifier
R-DME-59282
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
MAPK1, P40417
Locations in the PathwayBrowser
Expand all
Developmental Biology (Drosophila melanogaster)
Nervous system development (Drosophila melanogaster)
Axon guidance (Drosophila melanogaster)
L1CAM interactions (Drosophila melanogaster)
Signal transduction by L1 (Drosophila melanogaster)
MAP2K2 phosphorylates MAPK1 (Drosophila melanogaster)
p-S,T-MAP2K2:MAPK1 [cytosol] (Drosophila melanogaster)
rl [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF-independent MAPK1/3 activation (Drosophila melanogaster)
Cytosolic DUSPs dephosphorylate MAPKs (Drosophila melanogaster)
MAPK monomers and dimers [cytosol] (Drosophila melanogaster)
MAPK1 dimer [cytosol] (Drosophila melanogaster)
rl [cytosol] (Drosophila melanogaster)
rl [cytosol] (Drosophila melanogaster)
MAPK1 (ERK2) activation (Drosophila melanogaster)
MAP2K2 binds MAPK1 (Drosophila melanogaster)
p-S,T-MAP2K2:MAPK1 [cytosol] (Drosophila melanogaster)
rl [cytosol] (Drosophila melanogaster)
rl [cytosol] (Drosophila melanogaster)
MAP2K2 phosphorylates MAPK1 (Drosophila melanogaster)
p-S,T-MAP2K2:MAPK1 [cytosol] (Drosophila melanogaster)
rl [cytosol] (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
MAP2K and MAPK activation (Drosophila melanogaster)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
rl [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
rl [cytosol] (Drosophila melanogaster)
Dual mechanism MAPK inhibitors bind MAPKs (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
rl [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
rl [cytosol] (Drosophila melanogaster)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Drosophila melanogaster)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Drosophila melanogaster)
rl [cytosol] (Drosophila melanogaster)
MAP2Ks phosphorylate MAPK at the Golgi membrane (Drosophila melanogaster)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Drosophila melanogaster)
rl [cytosol] (Drosophila melanogaster)
MAP2Ks phosphorylate MAPKs (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
rl [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
rl [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
rl [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
rl [cytosol] (Drosophila melanogaster)
RAF phosphorylates MAP2K dimer (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
rl [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
rl [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
rl [cytosol] (Drosophila melanogaster)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
rl [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
rl [cytosol] (Drosophila melanogaster)
WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Drosophila melanogaster)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Drosophila melanogaster)
rl [cytosol] (Drosophila melanogaster)
rl [cytosol] (Drosophila melanogaster)
Negative regulation of MAPK pathway (Drosophila melanogaster)
Cytosolic DUSPs dephosphorylate MAPKs (Drosophila melanogaster)
MAPK monomers and dimers [cytosol] (Drosophila melanogaster)
MAPK1 dimer [cytosol] (Drosophila melanogaster)
rl [cytosol] (Drosophila melanogaster)
rl [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P40417
Gene Names
rl
Reference Genes
BioGPS Gene:3354888 rl
CTD Gene:3354888 rl
ENSEMBL:FBgn0003256
Flybase:FBgn0003256
KEGG Gene (Drosophila melanogaster):Dmel_CG12559 rl
Monarch:3354888 rl
NCBI Gene:3354888 rl
Reference Transcript
RefSeq:NM_001015121.3 rl
RefSeq:NM_001015122.3 rl
RefSeq:NM_001015123.3 rl
RefSeq:NM_001110878.4 rl
RefSeq:NM_001110879.2 rl
RefSeq:NM_001300706.2 rl
Other Identifiers
1629549_s_at
3354888
GO:0000003
GO:0000165
GO:0000166
GO:0000278
GO:0002376
GO:0003674
GO:0004672
GO:0004674
GO:0004707
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005829
GO:0006464
GO:0006468
GO:0006914
GO:0006950
GO:0007049
GO:0007165
GO:0007166
GO:0007173
GO:0007267
GO:0007362
GO:0007430
GO:0007465
GO:0007474
GO:0007476
GO:0007479
GO:0007552
GO:0007568
GO:0008134
GO:0008150
GO:0008283
GO:0008284
GO:0008286
GO:0008293
GO:0008340
GO:0008543
GO:0009056
GO:0009058
GO:0009267
GO:0009790
GO:0010468
GO:0016242
GO:0016301
GO:0016310
GO:0016740
GO:0019899
GO:0019901
GO:0022607
GO:0030054
GO:0030154
GO:0031594
GO:0034330
GO:0034334
GO:0034614
GO:0034641
GO:0035169
GO:0035170
GO:0035202
GO:0035556
GO:0043167
GO:0043226
GO:0045500
GO:0045793
GO:0046534
GO:0046843
GO:0048010
GO:0048149
GO:0048646
GO:0048856
GO:0050804
GO:0051091
GO:0051607
GO:0060446
GO:0070371
GO:0071243
GO:0071276
GO:0071310
GO:0090303
GO:2000826
GO:2001023
Participant Of
hasComponent
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane]
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane]
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane]
MAPK1 dimer [cytosol]
p-S,T-MAP2K2:MAPK1 [cytosol]
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane]
input
MAP2K2 binds MAPK1
WDR83:LAMTOR2:LAMTOR3 binds MAPK components
hasMember
MAPK monomers and dimers [cytosol]
Other forms of this molecule
rl [azurophil granule lumen]
rl [extracellular region]
rl [ficolin-1-rich granule lumen]
phospho-rl [cytosol]
phospho-rl [cytosol]
phospho-rl [cytosol]
rl [nucleoplasm]
rl [nucleoplasm]
rl [cytosol]
phospho-rl [cytosol]
phospho-rl [cytosol]
phospho-rl [nucleoplasm]
phospho-rl [nucleoplasm]
Inferred From
MAPK1 [cytosol] (Homo sapiens)
MAPKs [cytosol] (Homo sapiens)
Cross References
RefSeq
NP_001015123.1
,
NP_001015122.1
,
NP_001287635.1
,
NP_001104348.2
,
NP_001015121.3
,
NP_001104349.1
Flybase
FBgn0003256
PRO
P40417
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9U1H0 CIC
0.593
3
UniProt:Q24106 HID
0.59
3
UniProt:Q9V393 krz
8
krz [Golgi membrane]
(R-DME-350831)
krz [cytoplasmic vesicle membrane]
(R-DME-351187)
krz [lysosomal membrane]
(R-DME-432701)
krz [cytosol]
(R-DME-6783000-3)
krz [cytosol]
(R-DME-6783186)
Krz [cytosol]
(R-DME-2071841)
krz [cytosol]
(R-DME-416464-3)
krz [cytosol]
(R-DME-264470)
0.544
12
UniProt:Q24324 Dsor1
9
phospho-Dsor1 [cytosol]
(R-DME-5674490)
DSOR1 [cytosol]
(R-DME-205968)
Dsor1 [cytosol]
(R-DME-59504)
phospho-Dsor1 [cytosol]
(R-DME-169292)
Dsor1 [cytosol]
(R-DME-59502)
phospho-Dsor1 [cytosol]
(R-DME-112374)
phospho-Dsor1 [cytosol]
(R-DME-112339)
phospho-Dsor1 [cytosol]
(R-DME-109837)
phospho-Dsor1 [cytosol]
(R-DME-109848)
0.534
3
UniProt:Q24496 Q24496
0.524
2
UniProt:Q9W2K3 Q9W2K3
0.488
2
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