Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
SIAH2 [cytosol]
Stable Identifier
R-DME-374566
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
P21461
Locations in the PathwayBrowser
Expand all
Developmental Biology (Drosophila melanogaster)
Nervous system development (Drosophila melanogaster)
Axon guidance (Drosophila melanogaster)
Netrin-1 signaling (Drosophila melanogaster)
DCC interaction with SIAH2 (Drosophila melanogaster)
Homologues of SIAH2 [cytosol] (Drosophila melanogaster)
SIAH2 [cytosol] (Drosophila melanogaster)
NTN1:DCC:SIAH2 [plasma membrane] (Drosophila melanogaster)
Homologues of SIAH2 [cytosol] (Drosophila melanogaster)
SIAH2 [cytosol] (Drosophila melanogaster)
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Class I MHC mediated antigen processing & presentation (Drosophila melanogaster)
Antigen processing: Ubiquitination & Proteasome degradation (Drosophila melanogaster)
Interaction of E3 with substrate and E2-Ub complex (Drosophila melanogaster)
Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
Homologues of SIAH2 [cytosol] (Drosophila melanogaster)
SIAH2 [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
Homologues of SIAH2 [cytosol] (Drosophila melanogaster)
SIAH2 [cytosol] (Drosophila melanogaster)
Polyubiquitination of substrate (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
Homologues of SIAH2 [cytosol] (Drosophila melanogaster)
SIAH2 [cytosol] (Drosophila melanogaster)
E3:K48-polyubiquitinated substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
Homologues of SIAH2 [cytosol] (Drosophila melanogaster)
SIAH2 [cytosol] (Drosophila melanogaster)
E3:Ub:substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
Homologues of SIAH2 [cytosol] (Drosophila melanogaster)
SIAH2 [cytosol] (Drosophila melanogaster)
Release of E3 from polyubiquitinated substrate (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
Homologues of SIAH2 [cytosol] (Drosophila melanogaster)
SIAH2 [cytosol] (Drosophila melanogaster)
E3:K48-polyubiquitinated substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
Homologues of SIAH2 [cytosol] (Drosophila melanogaster)
SIAH2 [cytosol] (Drosophila melanogaster)
Transfer of Ub from E2 to substrate and release of E2 (Drosophila melanogaster)
Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
Homologues of SIAH2 [cytosol] (Drosophila melanogaster)
SIAH2 [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
Homologues of SIAH2 [cytosol] (Drosophila melanogaster)
SIAH2 [cytosol] (Drosophila melanogaster)
E3:Ub:substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
Homologues of SIAH2 [cytosol] (Drosophila melanogaster)
SIAH2 [cytosol] (Drosophila melanogaster)
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Deubiquitination (Drosophila melanogaster)
Ub-specific processing proteases (Drosophila melanogaster)
USP13 binds SIAH2 (Drosophila melanogaster)
Homologues of SIAH2 [cytosol] (Drosophila melanogaster)
SIAH2 [cytosol] (Drosophila melanogaster)
SIAH2:USP13 [cytosol] (Drosophila melanogaster)
Homologues of SIAH2 [cytosol] (Drosophila melanogaster)
SIAH2 [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P21461
Reference Genes
BioGPS Gene:39884
ENSEMBL:FBgn0003410
FlyBase:FBgn0003410
KEGG:dme:Dmel_CG9949
Monarch:39884
NCBI Gene:39884
UCSC:P21461
Reference Transcript
RefSeq:NM_001300160.1
RefSeq:NM_168689.2
RefSeq:NM_057377.4
Other Identifiers
153438_at
1632100_s_at
39884
GO:0000151
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0006511
GO:0007275
GO:0007423
GO:0007465
GO:0007601
GO:0008270
GO:0010498
GO:0016567
GO:0016740
GO:0030154
GO:0030163
GO:0031624
GO:0032436
GO:0035883
GO:0042802
GO:0043161
GO:0043226
GO:0045500
GO:0045676
GO:0046872
GO:0048856
GO:0050877
GO:0061630
GO:0140096
Participates
as a member of
Homologues of SIAH2 [cytosol] (Drosophila melanogaster)
Other forms of this molecule
SIAH1 [cytosol]
Inferred From
SIAH2 [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
FBpp0310636
,
FBgn0003410
,
FBtr0075333
,
FBtr0075332
,
FBtr0344230
,
FBpp0075092
,
FBpp0075091
FlyBase
FBgn0003410
PRO
P21461
Interactors (80)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q27934 PHYL
0.853
12
UniProt:Q9W3H5 Q9W3H5
0.742
5
UniProt:P42282 TTKA
0.681
4
UniProt:A1Z8K2 A1Z8K2
0.666
4
UniProt:Q9V3G9 Q9V3G9
0.621
3
UniProt:Q9W483 Q9W483
0.621
3
UniProt:Q9VFT4 Q9VFT4
0.621
3
UniProt:Q9VRY7 Q9VRY7
0.621
3
UniProt:P21461
2
SIAH2 [cytosol]
(R-DME-374566)
SIAH1 [cytosol]
(R-DME-374563)
0.573
2
UniProt:Q95RJ9
2
ebi [nucleoplasm]
(R-DME-351643)
ebi [nucleoplasm]
(R-DME-351644)
0.499
4
UniProt:Q9I7W2
4
Dmel\CG12106 [nucleoplasm]
(R-DME-8955108)
Dmel\CG12106 [cytosol]
(R-DME-8955113)
Dmel\CG12106 [extracellular region]
(R-DME-6806501)
Dmel\CG12106 [ficolin-1-rich granule lumen]
(R-DME-6801405)
0.488
2
UniProt:Q9VA79
1
UIP5 [cytosol]
(R-DME-976034)
0.488
2
UniProt:Q9VPZ1 Q9VPZ1
0.488
2
UniProt:Q24318-2 DP
0.488
2
UniProt:P35128 ben
6
BEN [cytosol]
(R-DME-205841)
ben [nucleoplasm]
(R-DME-8943013)
ben [nucleoplasm]
(R-DME-6790511)
ben [nucleoplasm]
(R-DME-5682541)
ben [cytosol]
(R-DME-8864210)
ben [cytosol]
(R-DME-206072)
0.488
2
UniProt:Q8T390
5
EndoA [Golgi membrane]
(R-DME-351189)
EndoA [plasma membrane]
(R-DME-177495)
EndoA [cytosol]
(R-DME-182958)
EndoA [cytosol]
(R-DME-8867734)
EndoA [cytosol]
(R-DME-8867732)
0.488
2
UniProt:Q9VIK7 Q9VIK7
0.488
2
UniProt:Q9VWS0 Q9VWS0
0.488
2
UniProt:Q8IHH3 Q8IHH3
0.488
2
UniProt:Q29R02 Q29R02
0.488
2
UniProt:Q9VB25
1
KIF16B [cytosol]
(R-DME-8849362)
0.488
2
UniProt:P05084 HUNB
0.488
2
UniProt:Q9VKU4 Q9VKU4
0.488
2
UniProt:O62602
6
lic [cytosol]
(R-DME-167998)
lic [cytosol]
(R-DME-168051)
phospho-lic [cytosol]
(R-DME-206255)
phospho-lic [cytosol]
(R-DME-167955)
phospho-lic [nucleoplasm]
(R-DME-450258)
phospho-lic [nucleoplasm]
(R-DME-450229)
0.488
2
UniProt:Q8INY6 Q8INY6
0.488
2
UniProt:Q8INY5 Q8INY5
0.488
2
UniProt:Q9VZJ1 Q9VZJ1
0.488
2
UniProt:Q9V3M9 Q9V3M9
0.488
2
UniProt:Q4V6Y7 Q4V6Y7
0.488
2
UniProt:Q9VRN5
1
LIN28A [cytosol]
(R-DME-500391)
0.488
2
UniProt:Q9W2P8 Q9W2P8
0.488
2
UniProt:Q9VLF2 Q9VLF2
0.488
2
UniProt:Q9VW77 Q9VW77
0.488
2
UniProt:C6SV46 C6SV46
0.488
2
UniProt:M9PHB8 M9PHB8
0.488
2
UniProt:Q9VPV6 Q9VPV6
0.488
2
UniProt:A1Z8D4 A1Z8D4
0.488
2
UniProt:Q7K2G1-2 RPN13
0.488
2
UniProt:A0A4D6K416 A0A4D6K416
0.488
2
UniProt:Q9W2A3 Q9W2A3
0.488
2
UniProt:Q9VL73 Q9VL73
0.488
2
UniProt:Q05856
3
SmB [nucleoplasm]
(R-DME-71896)
SmB [nucleoplasm]
(R-DME-192213)
SmB [cytosol]
(R-DME-191798)
0.488
2
UniProt:Q0IGU0 Q0IGU0
0.488
2
UniProt:Q9W0A2 Q9W0A2
0.488
2
UniProt:Q058Z8 Q058Z8
0.488
2
UniProt:Q9VDX4 Q9VDX4
0.488
2
UniProt:P82295 PROML
0.488
2
UniProt:P23792 DISC
0.488
2
UniProt:Q9VNE1
1
PolZ2 [nucleoplasm]
(R-DME-59092)
0.488
2
UniProt:Q9VBQ3
1
Dmel\CG5111 [cytosol]
(R-DME-8956129)
0.488
2
UniProt:P22293
2
su(sable) [nucleoplasm]
(R-DME-9930063)
su(sable) [nucleoplasm]
(R-DME-6807406)
0.488
2
UniProt:Q961D1
1
CycK [nucleoplasm]
(R-DME-6796619)
0.488
2
UniProt:Q9VDP8
1
mdlc [nucleoplasm]
(R-DME-9769563)
0.488
2
UniProt:Q9VRL1 Uev1A
4
UEV1A [cytosol]
(R-DME-206024)
Uev1A [cytosol]
(R-DME-947624)
Uev1A [nucleoplasm]
(R-DME-5682543)
Uev1A [cytosol]
(R-DME-205753)
0.488
2
UniProt:P52486
2
Ubc4 [cytosol]
(R-DME-8864200)
Ubc4 [cytosol]
(R-DME-934631)
0.488
2
UniProt:P52487
2
Ubc84D [nucleoplasm]
(R-DME-5653666)
Ubc84D [cytosol]
(R-DME-936014)
0.488
2
UniProt:Q9XZ57 Q9XZ57
0.488
2
UniProt:Q01070 ESMC
0.488
2
UniProt:P23023-2 DSX
0.488
2
UniProt:Q9W0B3
1
Vta1 [cytosol]
(R-DME-917735)
0.488
2
UniProt:Q058W3 Q058W3
0.488
2
UniProt:Q29QK1 Q29QK1
0.488
2
UniProt:Q9GQQ0-3 SPIN
0.488
2
UniProt:A1Z904 A1Z904
0.488
2
UniProt:Q9VWN5 MINY3
0.488
2
UniProt:Q9W4B3 Q9W4B3
0.488
2
UniProt:P17789 TTKB
0.488
2
UniProt:Q961J0 Q961J0
0.488
2
UniProt:Q8I942 Q8I942
0.488
2
UniProt:P23758
1
Poxn [nucleoplasm]
(R-DME-158583-2)
0.488
2
UniProt:P40417
14
phospho-p-T185,Y187-MAPK1 [nucleoplasm]
(R-DME-112354)
phospho-p-T202,Y204-MAPK3 [nucleoplasm]
(R-DME-112359)
phospho-p-T202,Y204-MAPK3 [cytosol]
(R-DME-109842)
phospho-p-T185,Y187-MAPK1 [cytosol]
(R-DME-109853)
MAPK1 [cytosol]
(R-DME-59282)
MAPK3 [cytosol]
(R-DME-59284)
MAPK3 [nucleoplasm]
(R-DME-73724)
MAPK1 [nucleoplasm]
(R-DME-199960)
phospho-p-T185-MAPK1 [cytosol]
(R-DME-9635773)
phospho-p-T202-MAPK3 [cytosol]
(R-DME-9635775)
phospho-p-Y204-MAPK3-3 [cytosol]
(R-DME-2422448)
MAPK1 [ficolin-1-rich granule lumen]
(R-DME-6800964)
MAPK1 [extracellular region]
(R-DME-6806250)
MAPK1 [azurophil granule lumen]
(R-DME-6799225)
0.488
2
UniProt:D5A7J7 D5A7J7
0.488
2
UniProt:C6SV53 C6SV53
0.488
2
UniProt:Q9W481
1
Dmel\CG15771 [cytosol]
(R-DME-4085391)
0.488
2
UniProt:Q9VJS5
5
Dmel\CG3473 [nucleoplasm]
(R-DME-8943013-2)
Dmel\CG3473 [nucleoplasm]
(R-DME-6790511-2)
Dmel\CG3473 [nucleoplasm]
(R-DME-5682541-2)
Dmel\CG3473 [cytosol]
(R-DME-8864210-2)
Dmel\CG3473 [cytosol]
(R-DME-206072-2)
0.488
2
UniProt:Q5BIB4 Q5BIB4
0.488
2
UniProt:P23757 POXM
0.488
2
UniProt:Q9Y106 MB21L
0.488
2
UniProt:Q9VIE6
1
Mcm10 [nucleoplasm]
(R-DME-68403)
0.488
2
UniProt:Q9VQU9 BOWEL
0.488
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text