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phospho-Dsor1 [cytosol]
Stable Identifier
R-DME-169292
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
p-S222,S226-MAP2K2, Q24324
Locations in the PathwayBrowser
Expand all
Signal Transduction (Drosophila melanogaster)
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
MAP2K and MAPK activation (Drosophila melanogaster)
Dissociation of RAS:RAF complex (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S222,S226 MAP2K2 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S222,S226 MAP2K2 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
Dual mechanism MAPK inhibitors bind MAPKs (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S222,S226 MAP2K2 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S222,S226 MAP2K2 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Drosophila melanogaster)
WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S222,S226 MAP2K2 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
MAP2Ks phosphorylate MAPK at the Golgi membrane (Drosophila melanogaster)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S222,S226 MAP2K2 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
IL17RD:p-2S MAP2Ks:p-T,Y MAPKs [Golgi membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S222,S226 MAP2K2 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S222,S226 MAP2K2 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
MAP2Ks phosphorylate MAPKs (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S222,S226 MAP2K2 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S222,S226 MAP2K2 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S222,S226 MAP2K2 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S222,S226 MAP2K2 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S222,S226 MAP2K2 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
RAF phosphorylates MAP2K dimer (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S222,S226 MAP2K2 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S222,S226 MAP2K2 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S222,S226 MAP2K2 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S222,S226 MAP2K2 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S222,S226 MAP2K2 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
Negative regulation of MAPK pathway (Drosophila melanogaster)
Negative feedback regulation of MAPK pathway (Drosophila melanogaster)
Activated MAPKs phosphorylate MAP2K1 (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-2S,T MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
RAF activation (Drosophila melanogaster)
Phosphorylation of RAF (Drosophila melanogaster)
RAF activating kinases [plasma membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S222,S226 MAP2K2 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by NTRKs (Drosophila melanogaster)
Signaling by NTRK1 (TRKA) (Drosophila melanogaster)
Signalling to ERKs (Drosophila melanogaster)
Prolonged ERK activation events (Drosophila melanogaster)
Frs2-mediated activation (Drosophila melanogaster)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Drosophila melanogaster)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S222,S226 MAP2K2 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
Dissociation of phosphorylated MAP2Ks and MAPKs (Drosophila melanogaster)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S222,S226 MAP2K2 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S222,S226 MAP2K2 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Drosophila melanogaster)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S222,S226 MAP2K2 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Drosophila melanogaster)
p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
p-S222,S226 MAP2K2 dimer [cytosol] (Drosophila melanogaster)
phospho-Dsor1 [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q24324 Dsor1
Gene Names
Dsor1, CG15793
Chain
chain:1-396
Reference Genes
BioGPS Gene:31872 Dsor1
KEGG:dme:Dmel_CG15793 Dsor1
Monarch:31872 Dsor1
NCBI Gene:31872 Dsor1
UCSC:Q24324 Dsor1
Reference Transcript
RefSeq:NM_078543.4 Dsor1
RefSeq:NM_001298115.1 Dsor1
Other Identifiers
154939_at
1626006_at
31872
GO:0000122
GO:0000165
GO:0000166
GO:0000793
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004708
GO:0004712
GO:0004713
GO:0005515
GO:0005524
GO:0005635
GO:0005694
GO:0005829
GO:0006355
GO:0006468
GO:0007095
GO:0007173
GO:0007298
GO:0007362
GO:0007430
GO:0007465
GO:0008286
GO:0008293
GO:0008340
GO:0008543
GO:0009953
GO:0016301
GO:0016740
GO:0019900
GO:0030154
GO:0033314
GO:0042386
GO:0042461
GO:0045500
GO:0045944
GO:0048010
GO:0048856
GO:0048870
GO:0051607
GO:0070371
GO:0071481
GO:0098542
GO:0106310
GO:0140096
Participates
as a component of
p-2S,T MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
p-S222,S226 MAP2K2 dimer [cytosol] (Drosophila melanogaster)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
Other forms of this molecule
DSOR1 [cytosol]
phospho-Dsor1 [cytosol]
phospho-Dsor1 [cytosol]
phospho-Dsor1 [cytosol]
phospho-Dsor1 [cytosol]
Dsor1 [cytosol]
Dsor1 [cytosol]
phospho-Dsor1 [cytosol]
Inferred From
p-S222,S226-MAP2K2 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 222 (in Homo sapiens)
Coordinate
222
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 226 (in Homo sapiens)
Coordinate
226
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001285044.1
,
NP_511098.1
ENSEMBL
FBtr0071313
,
FBpp0071248
,
FBgn0010269
FlyBase
FBgn0010269
PRO
Q24324
PDB
8BW9
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11346 Raf
20
Phospho PHL [plasma membrane]
(R-DME-205859)
PHL [cytosol]
(R-DME-205713)
phospho-Raf [cytosol]
(R-DME-5672646)
phospho-Raf [cytosol]
(R-DME-5672676)
phospho-Raf [cytosol]
(R-DME-5672664)
phospho-Raf [cytosol]
(R-DME-5672673)
phospho-Raf [plasma membrane]
(R-DME-5672679)
phospho-Raf [plasma membrane]
(R-DME-5672648)
phospho-Raf [plasma membrane]
(R-DME-5672665)
phospho-Raf [cytosol]
(R-DME-5672681)
phospho-Raf [cytosol]
(R-DME-206028)
Raf [cytosol]
(R-DME-167205)
phospho-Raf [plasma membrane]
(R-DME-5675199)
phospho-Raf [plasma membrane]
(R-DME-5675193)
phospho-Raf [plasma membrane]
(R-DME-5675420)
phospho-Raf [plasma membrane]
(R-DME-206222)
phospho-Raf [cytosol]
(R-DME-5672639)
phospho-Raf [cytosol]
(R-DME-109786)
phospho-Raf [cytosol]
(R-DME-5672667)
Raf [cytosol]
(R-DME-167224)
0.667
5
UniProt:P40417
14
phospho-rl [nucleoplasm]
(R-DME-112354)
phospho-rl [nucleoplasm]
(R-DME-112359)
phospho-rl [cytosol]
(R-DME-109842)
phospho-rl [cytosol]
(R-DME-109853)
rl [cytosol]
(R-DME-59282)
rl [cytosol]
(R-DME-59284)
rl [nucleoplasm]
(R-DME-73724)
rl [nucleoplasm]
(R-DME-199960)
phospho-rl [cytosol]
(R-DME-9635773)
phospho-rl [cytosol]
(R-DME-9635775)
phospho-rl [cytosol]
(R-DME-2422448)
rl [azurophil granule lumen]
(R-DME-6799225)
rl [extracellular region]
(R-DME-6806250)
rl [ficolin-1-rich granule lumen]
(R-DME-6800964)
0.534
2
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