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About
What is Reactome ?
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Table of Contents
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phospho-p-S445,T599,S602,S729 BRAF [cytosol]
Stable Identifier
R-DME-5672676
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
P11346
Locations in the PathwayBrowser
Expand all
Signal Transduction (Drosophila melanogaster)
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
MAP2K and MAPK activation (Drosophila melanogaster)
Dissociation of RAS:RAF complex (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
Dual mechanism MAPK inhibitors bind MAPKs (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Drosophila melanogaster)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Drosophila melanogaster)
activated RAF homo/heterodimer [cytosol] (Drosophila melanogaster)
activated RAF monomer [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane] (Drosophila melanogaster)
activated RAF homo/heterodimer [cytosol] (Drosophila melanogaster)
activated RAF monomer [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
MAP2Ks and MAPKs bind to the activated RAF complex (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Drosophila melanogaster)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
MAP2Ks phosphorylate MAPKs (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
RAF phosphorylates MAP2K dimer (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAF:YWHAB dimer [cytosol] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Drosophila melanogaster)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Drosophila melanogaster)
activated RAF homo/heterodimer [cytosol] (Drosophila melanogaster)
activated RAF monomer [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
activated RAF homo/heterodimer [cytosol] (Drosophila melanogaster)
activated RAF monomer [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
Negative regulation of MAPK pathway (Drosophila melanogaster)
PEBP1 binds activated RAF1 (Drosophila melanogaster)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Drosophila melanogaster)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
PP2A dephosphorylates RAF1 (Drosophila melanogaster)
p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
p21RAS:GTP:p-S621 RAF1 homo/heterodimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
PP5 dephosphorylates RAF1 S338 (Drosophila melanogaster)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
RAF activation (Drosophila melanogaster)
"Activator" RAF:YWHAB dimer binds RAS:GTP (Drosophila melanogaster)
'activator' RAF:YWHAB dimer [cytosol] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAF:YWHAB dimer [cytosol] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
Phosphorylation of RAF (Drosophila melanogaster)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAF:YWHAB dimer [cytosol] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAF:YWHAB dimer [cytosol] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAF:YWHAB dimer [cytosol] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
Raf dimer inhibitors bind RAF heterodimers (Drosophila melanogaster)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAF:YWHAB dimer [cytosol] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Drosophila melanogaster)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Drosophila melanogaster)
'activator' RAF:YWHAB dimer [cytosol] (Drosophila melanogaster)
'activator' RAFs [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by NTRKs (Drosophila melanogaster)
Signaling by NTRK1 (TRKA) (Drosophila melanogaster)
Signalling to ERKs (Drosophila melanogaster)
Prolonged ERK activation events (Drosophila melanogaster)
Frs2-mediated activation (Drosophila melanogaster)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Drosophila melanogaster)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Drosophila melanogaster)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Drosophila melanogaster)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Drosophila melanogaster)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Drosophila melanogaster)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Drosophila melanogaster)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Drosophila melanogaster)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Drosophila melanogaster)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Drosophila melanogaster)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
BRAF autophosphorylates downstream of RAP1 and NGF (Drosophila melanogaster)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Drosophila melanogaster)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
Dissociation of phosphorylated MAP2Ks and MAPKs (Drosophila melanogaster)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Drosophila melanogaster)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Drosophila melanogaster)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Drosophila melanogaster)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Drosophila melanogaster)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Drosophila melanogaster)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Drosophila melanogaster)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Drosophila melanogaster)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Drosophila melanogaster)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P11346 Raf
Gene Names
Raf, ph, phl, CG2845
Chain
chain:1-739
Reference Genes
BioGPS Gene:31221 Raf
CTD Gene:31221 Raf
KEGG Gene (Drosophila melanogaster):Dmel_CG2845 Raf
Monarch:31221 Raf
NCBI Gene:31221 Raf
UCSC:P11346 Raf
Reference Transcript
RefSeq:NM_080308.4 Raf
RefSeq:NM_001103397.3 Raf
Other Identifiers
143302_at
1627470_at
31221
GO:0000165
GO:0000166
GO:0000186
GO:0002168
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004709
GO:0005515
GO:0005524
GO:0005622
GO:0005737
GO:0005829
GO:0005886
GO:0006468
GO:0006914
GO:0007163
GO:0007165
GO:0007173
GO:0007265
GO:0007283
GO:0007298
GO:0007362
GO:0007369
GO:0007427
GO:0007430
GO:0007465
GO:0007472
GO:0007474
GO:0007476
GO:0007552
GO:0007623
GO:0008069
GO:0008152
GO:0008284
GO:0008293
GO:0008543
GO:0009267
GO:0012501
GO:0016242
GO:0016301
GO:0016310
GO:0016740
GO:0019900
GO:0022414
GO:0023052
GO:0030154
GO:0030641
GO:0035171
GO:0035309
GO:0036211
GO:0040014
GO:0042051
GO:0042386
GO:0042461
GO:0045500
GO:0046530
GO:0046534
GO:0046777
GO:0046843
GO:0046872
GO:0048010
GO:0048856
GO:0048870
GO:0070371
GO:0070374
GO:0106310
GO:0140096
GO:2001234
Participates
as a member of
activated RAF monomer [cytosol] (Drosophila melanogaster)
as a component of
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Drosophila melanogaster)
as a candidate of
'activator' RAFs [cytosol] (Drosophila melanogaster)
Other forms of this molecule
Phospho PHL [plasma membrane]
PHL [cytosol]
RAF1 [cytosol]
phospho-p-S338,Y340,Y341-RAF1 [cytosol]
phospho-p-S338-RAF1 [cytosol]
BRAF [cytosol]
phospho-hyperphosphorylated BRAF [plasma membrane]
phospho-hyperphosphorylated RAF1 [plasma membrane]
phospho-p-S299,S302,T452,T455,S576 ARAF [cytosol]
phospho-p-S338,Y341,T491,S494,S621 RAF1 [cytosol]
phospho-p-S445,S729-BRAF [cytosol]
phospho-p-S445,T599,S602,S729 BRAF [plasma membrane]
phospho-p-S299,S302,T452,T455,S576 ARAF [plasma membrane]
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]
phospho-p-S576 ARAF [cytosol]
phospho-p-S621-RAF1 [cytosol]
phospho-p-S214,S576 ARAF [cytosol]
phospho-p-S259,S621-RAF1 [cytosol]
phospho-p-S365,S445,S729 BRAF [cytosol]
phospho-p-Y341,T491,S494,S621 RAF1 [plasma membrane]
phospho-p-S621-RAF1 [plasma membrane]
Inferred From
p-S445,T599,S602,S729 BRAF [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 445 (in Homo sapiens)
Coordinate
445
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 729 (in Homo sapiens)
Coordinate
729
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 599 (in Homo sapiens)
Coordinate
599
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 602 (in Homo sapiens)
Coordinate
602
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_525047.1
,
NP_001096867.3
Flybase
FBgn0003079
IntEnz
2.7.11.1
PRO
P11346
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q24324 Dsor1
9
DSOR1 [cytosol]
(R-DME-205968)
phospho-p-S,218, S222,T292 MAP2K1 [cytosol]
(R-DME-5674490)
phospho-p-S,T-MAP2K2 [cytosol]
(R-DME-109848)
phospho-p-T286,T292-MAP2K1 [cytosol]
(R-DME-112374)
phospho-p-S218,S222,T286,T292-MAP2K1 [cytosol]
(R-DME-112339)
MAP2K1 [cytosol]
(R-DME-59502)
MAP2K2 [cytosol]
(R-DME-59504)
phospho-p-S222,S226-MAP2K2 [cytosol]
(R-DME-169292)
phospho-p-S218,S222-MAP2K1 [cytosol]
(R-DME-109837)
0.667
5
UniProt:P00528
20
SRC [cytosol]
(R-DME-9628701)
phospho-p-Y416-SRC [cytosol]
(R-DME-8964276)
FGR [extracellular region]
(R-DME-6806524)
FGR [secretory granule lumen]
(R-DME-6804974)
MyrG-SRC [plasma membrane]
(R-DME-8876922)
phospho-p-Y419-SRC-1 [plasma membrane]
(R-DME-112331)
phospho-p-Y394-LCK [plasma membrane]
(R-DME-8857940)
LYN [plasma membrane]
(R-DME-197943)
phospho-p-Y397-LYN [cytosol]
(R-DME-8942608)
SRC-2 [cytosol]
(R-DME-191648)
FYN [cytosol]
(R-DME-200917)
LCK [cytosol]
(R-DME-167609)
phospho-MyrG-p-Y419-SRC [plasma membrane]
(R-DME-1810408)
phospho-MyrG-p-Y426-YES1 [plasma membrane]
(R-DME-1810411)
phospho-MyrG-p-Y420-FYN [plasma membrane]
(R-DME-1810410)
phospho-MyrG,p-Y530-SRC [plasma membrane]
(R-DME-377598)
LYN [cytosol]
(R-DME-354251)
phospho-p-Y419-SRC [cytosol]
(R-DME-377592)
SRC-1 [plasma membrane]
(R-DME-65043)
FGR [cytosol]
(R-DME-432116)
0.544
3
UniProt:P08646 Ras85D
20
S-Farn-Me-PalmS KRAS [plasma membrane]
(R-DME-9674814)
phospho-p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane]
(R-DME-9674821)
NRAS [tertiary granule membrane]
(R-DME-6800190)
phospho-pS181-S-Farn-Me KRAS4B [mitochondrial outer membrane]
(R-DME-9653578)
S-Farn-Me KRAS4B [cytosol]
(R-DME-9654510)
phospho-pS181-S-Farn-Me KRAS4B [plasma membrane]
(R-DME-9653482)
RAS85D [plasma membrane]
(R-DME-205933)
S-Farn-Me PalmS KRAS4A [Golgi membrane]
(R-DME-9647903)
S-Farn-Me PalmS HRAS [Golgi membrane]
(R-DME-9647896)
S-Farn-Me PalmS NRAS [Golgi membrane]
(R-DME-9647906)
S-Farn-Me HRAS [endoplasmic reticulum membrane]
(R-DME-9647796)
S-Farn NRAS [endoplasmic reticulum membrane]
(R-DME-9647782)
S-Farn-KRAS [endoplasmic reticulum membrane]
(R-DME-9647790)
S-Farn-proNRAS [endoplasmic reticulum membrane]
(R-DME-9647928)
S-Farn-proKRAS [endoplasmic reticulum membrane]
(R-DME-9647925)
proKRAS [cytosol]
(R-DME-9647762)
pro-KRAS4A [cytosol]
(R-DME-9649683)
S-Farn-Me-2xPalmS HRAS [plasma membrane]
(R-DME-9647912)
S-Farn-Me-PalmS KRAS4A [plasma membrane]
(R-DME-9647915)
S-Farn-Me PalmS NRAS [plasma membrane]
(R-DME-9647910)
0.502
2
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