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daf-16 [nucleoplasm]
Stable Identifier
R-CEL-199305
Type
Protein [EntityWithAccessionedSequence]
Species
Caenorhabditis elegans
Compartment
nucleoplasm
Synonyms
FOXO3, O16850
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Caenorhabditis elegans)
Cellular responses to stress (Caenorhabditis elegans)
Mitochondrial unfolded protein response (UPRmt) (Caenorhabditis elegans)
FOXO3 translocates from the mitochondrial matrix to the nucleus (Caenorhabditis elegans)
daf-16 [nucleoplasm] (Caenorhabditis elegans)
Developmental Biology (Caenorhabditis elegans)
Signaling by NODAL (Caenorhabditis elegans)
Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Caenorhabditis elegans)
SMAD2,3:SMAD4:FOXO3:FoxO3a-binding Element [nucleoplasm] (Caenorhabditis elegans)
daf-16 [nucleoplasm] (Caenorhabditis elegans)
daf-16 [nucleoplasm] (Caenorhabditis elegans)
Gene expression (Transcription) (Caenorhabditis elegans)
RNA Polymerase II Transcription (Caenorhabditis elegans)
Generic Transcription Pathway (Caenorhabditis elegans)
FOXO-mediated transcription (Caenorhabditis elegans)
Regulation of FOXO transcriptional activity by acetylation (Caenorhabditis elegans)
KAT2B,EP300 acetylate FOXO3 under oxidative stress (Caenorhabditis elegans)
daf-16 [nucleoplasm] (Caenorhabditis elegans)
SIRT1,SIRT3 deacetylate FOXO3 (Caenorhabditis elegans)
daf-16 [nucleoplasm] (Caenorhabditis elegans)
Immune System (Caenorhabditis elegans)
Cytokine Signaling in Immune system (Caenorhabditis elegans)
FLT3 Signaling (Caenorhabditis elegans)
AKT phosphorylates FOXO3 downstream of FLT3 (Caenorhabditis elegans)
daf-16 [nucleoplasm] (Caenorhabditis elegans)
Signal Transduction (Caenorhabditis elegans)
Signaling by Nuclear Receptors (Caenorhabditis elegans)
ESR-mediated signaling (Caenorhabditis elegans)
Extra-nuclear estrogen signaling (Caenorhabditis elegans)
Estrogen-dependent nuclear events downstream of ESR-membrane signaling (Caenorhabditis elegans)
AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Caenorhabditis elegans)
daf-16 [nucleoplasm] (Caenorhabditis elegans)
External Reference Information
External Reference
UniProt:O16850
Gene Names
daf-16
Reference Genes
BioGPS Gene:172981 daf-16
CTD Gene:172981 daf-16
ENSEMBL:WBGene00000912
KEGG:cel:CELE_R13H8.1 daf-16
Monarch:172981 daf-16
NCBI Gene:172981 daf-16
UCSC:O16850 daf-16
Wormbase:WBGene00000912
Wormbase:WBGene00000912 daf-16
Reference Transcript
RefSeq:NM_001377627.2 daf-16
RefSeq:NM_001377628.3 daf-16
RefSeq:NM_001026422.6 daf-16
RefSeq:NM_001026427.7 daf-16
RefSeq:NM_001381205.1 daf-16
RefSeq:NM_001026426.2 daf-16
RefSeq:NM_001264561.1 daf-16
RefSeq:NM_001381210.1 daf-16
RefSeq:NM_001026424.4 daf-16
RefSeq:NM_001026425.6 daf-16
RefSeq:NM_001026423.4 daf-16
Other Identifiers
172981
GO:0000122
GO:0000978
GO:0000981
GO:0001228
GO:0002119
GO:0002376
GO:0002821
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0006355
GO:0006357
GO:0006974
GO:0006979
GO:0007614
GO:0008013
GO:0008286
GO:0008340
GO:0008582
GO:0009411
GO:0010286
GO:0010468
GO:0010564
GO:0010628
GO:0010629
GO:0010883
GO:0017151
GO:0019899
GO:0030431
GO:0031625
GO:0032436
GO:0034599
GO:0034605
GO:0035556
GO:0040015
GO:0040024
GO:0042594
GO:0043065
GO:0043226
GO:0043565
GO:0045087
GO:0045887
GO:0045944
GO:0046890
GO:0048856
GO:0050829
GO:0050830
GO:0050877
GO:0051457
GO:0060537
GO:0061065
GO:0061066
GO:0071889
GO:0098542
GO:0140110
GO:0140297
GO:1900075
GO:1900426
GO:1905909
GO:1990381
Participates
as an input of
AKT phosphorylates FOXO3 downstream of FLT3 (Caenorhabditis elegans)
Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Caenorhabditis elegans)
KAT2B,EP300 acetylate FOXO3 under oxidative stress (Caenorhabditis elegans)
AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Caenorhabditis elegans)
as a component of
SMAD2,3:SMAD4:FOXO3:FoxO3a-binding Element [nucleoplasm] (Caenorhabditis elegans)
FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Caenorhabditis elegans)
as an output of
FOXO3 translocates from the mitochondrial matrix to the nucleus (Caenorhabditis elegans)
SIRT1,SIRT3 deacetylate FOXO3 (Caenorhabditis elegans)
Other forms of this molecule
daf-16 [nucleoplasm]
daf-16 [nucleoplasm]
daf-16 [nucleoplasm]
phospho-daf-16 [nucleoplasm]
phospho-daf-16 [nucleoplasm]
phospho-daf-16 [nucleoplasm]
phospho-daf-16 [nucleoplasm]
phospho-daf-16 [cytosol]
phospho-daf-16 [cytosol]
phospho-daf-16 [cytosol]
daf-16 [nucleoplasm]
daf-16 [mitochondrial matrix]
daf-16 [mitochondrial matrix]
daf-16 [cytosol]
daf-16 [nucleoplasm]
phospho-daf-16 [cytosol]
phospho-daf-16 [nucleoplasm]
phospho-daf-16 [nucleoplasm]
Inferred From
FOXO3,(FOXO1) [nucleoplasm]
(Homo sapiens)
FOXO3,FOXO4,(FOXO1) [nucleoplasm]
(Homo sapiens)
FOXO3,FOXO4 [nucleoplasm]
(Homo sapiens)
FOXO3,(FOXO1,FOXO4) [nucleoplasm]
(Homo sapiens)
FOXO3 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_001021594.1
,
NP_001021598.2
,
NP_001367893.1
,
NP_001021595.1
,
NP_001367892.1
,
NP_001364784.1
,
NP_001364785.1
,
NP_001021593.1
,
NP_001021596.1
,
NP_001251490.1
,
NP_001021597.1
ENSEMBL
R13H8.1h.1
,
R13H8.1h.1
,
WBGene00000912
PRO
O16850
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q17941
20
phospho-akt-1 [nucleoplasm]
(R-CEL-202087)
phospho-akt-1 [nucleoplasm]
(R-CEL-3009365)
phospho-akt-1 [nucleoplasm]
(R-CEL-198357)
phospho-akt-1 [cytosol]
(R-CEL-3009367)
phospho-akt-1 [cytosol]
(R-CEL-202062)
phospho-akt-1 [cytosol]
(R-CEL-198356)
phospho-akt-1 [plasma membrane]
(R-CEL-2317312)
phospho-akt-1 [plasma membrane]
(R-CEL-3009363)
phospho-akt-1 [plasma membrane]
(R-CEL-377265)
akt-1 [plasma membrane]
(R-CEL-202053)
akt-1 [plasma membrane]
(R-CEL-2976006)
akt-1 [plasma membrane]
(R-CEL-199416)
akt-1 [cytosol]
(R-CEL-49859)
akt-1 [cytosol]
(R-CEL-2976007)
akt-1 [cytosol]
(R-CEL-58252)
phospho-akt-1 [cytosol]
(R-CEL-202066)
phospho-akt-1 [cytosol]
(R-CEL-3009370)
phospho-akt-1 [cytosol]
(R-CEL-198634)
phospho-akt-1 [cytosol]
(R-CEL-8848757)
phospho-akt-1 [plasma membrane]
(R-CEL-199430)
0.676
3
UniProt:Q9XTG7
15
phospho-akt-2 [cytosol]
(R-CEL-9841264-2)
phospho-akt-2 [plasma membrane]
(R-CEL-199430-2)
phospho-akt-2 [cytosol]
(R-CEL-8848757-2)
phospho-akt-2 [cytosol]
(R-CEL-198634-2)
phospho-akt-2 [cytosol]
(R-CEL-202066-2)
akt-2 [cytosol]
(R-CEL-58252-2)
akt-2 [cytosol]
(R-CEL-49859-2)
akt-2 [plasma membrane]
(R-CEL-199416-2)
akt-2 [plasma membrane]
(R-CEL-202053-2)
phospho-akt-2 [plasma membrane]
(R-CEL-377265-2)
phospho-akt-2 [plasma membrane]
(R-CEL-2317312-2)
phospho-akt-2 [cytosol]
(R-CEL-198356-2)
phospho-akt-2 [cytosol]
(R-CEL-202062-2)
phospho-akt-2 [nucleoplasm]
(R-CEL-198357-2)
phospho-akt-2 [nucleoplasm]
(R-CEL-202087-2)
0.676
3
UniProt:Q2PJ68
6
sgk-1 [cytosol]
(R-CEL-2682351)
sgk-1 [cytosol]
(R-CEL-2682364)
sgk-1 [cytosol]
(R-CEL-2682356)
phospho-sgk-1 [cytosol]
(R-CEL-6795313)
phospho-sgk-1 [cytosol]
(R-CEL-6795449)
phospho-sgk-1 [nucleoplasm]
(R-CEL-9612512)
0.676
3
UniProt:Q21921
1
sir-2.1 [nucleoplasm]
(R-CEL-427531)
0.589
2
IntAct:EBI-16221250 HCF1
0.524
2
UniProt:Q9N5V3 Q9N5V3
0.488
2
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