Reactome | daf-16 [nucleoplasm]

daf-16 [nucleoplasm]

Stable Identifier

R-CEL-6782501

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

PolyUb-FOXO4, O16850

Locations in the PathwayBrowser

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Metabolism of proteins (Caenorhabditis elegans)

- Post-translational protein modification (Caenorhabditis elegans)
  - Deubiquitination (Caenorhabditis elegans)
    - Ub-specific processing proteases (Caenorhabditis elegans)
      - USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Caenorhabditis elegans)
        
        USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Caenorhabditis elegans)
        
        PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Caenorhabditis elegans)
        
        daf-16 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:O16850

Gene Names

daf-16

Reference Genes

BioGPS Gene:172981 daf-16

CTD Gene:172981 daf-16

ENSEMBL:WBGene00000912

KEGG:cel:CELE_R13H8.1 daf-16

Monarch:172981 daf-16

NCBI Gene:172981 daf-16

UCSC:O16850 daf-16

Wormbase:WBGene00000912

Wormbase:WBGene00000912 daf-16

Reference Transcript

Other Identifiers

172981

175678_at

175823_s_at

181992_s_at

18458719

188176_s_at

A_12_P105570

A_12_P111652

A_12_P112051

A_12_P141320

A_12_P141321

CE28771

CE31056

CE_WBGene00000912_A

CE_WBGene00000912_B

CGZ0032220

CGZ0032221

CGZ0032224

CGZ0032226

CGZ0032229

GO:0000122

GO:0000977

GO:0000978

GO:0000981

GO:0002119

GO:0002376

GO:0002821

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0006355

GO:0006357

GO:0006974

GO:0006979

GO:0007614

GO:0008013

GO:0008286

GO:0008340

GO:0008582

GO:0009411

GO:0010286

GO:0010468

GO:0010564

GO:0010628

GO:0010629

GO:0010883

GO:0017151

GO:0019899

GO:0030431

GO:0031625

GO:0032436

GO:0034599

GO:0034605

GO:0035556

GO:0040015

GO:0040024

GO:0042594

GO:0043065

GO:0043226

GO:0043565

GO:0045087

GO:0045887

GO:0045944

GO:0046890

GO:0048856

GO:0050829

GO:0050830

GO:0050877

GO:0051220

GO:0051457

GO:0060537

GO:0061065

GO:0061066

GO:0071889

GO:0098542

GO:0140110

GO:0140297

GO:1900075

GO:1900426

GO:1905909

GO:1990381

R13H8.1

R13H8.1a

R13H8.1b

R13H8.1c

R13H8.1d

R13H8.1f_1222-1281_0.901_14_C

R13H8.1f_827-886_0.906_13_A

R13H8.1f_945-1004_0.889_19_B

R13H8_1aP00173

R13H8_1aP00255

R13H8_1aP00482

R13H8_1bP00140

R13H8_1bP00444

R13H8_1bP01058

R13H8_1cP00139

R13H8_1dP00133

R13H8_1eP00055

R13H8_1eP00843

WBGene00000912

cea2.3.21962

cea2.c.05579

cea2.d.05039

cea2.d.35895

cea2.d.35914

cea2.d.35915

cea2.d.35932

Participates

as a member of

PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Caenorhabditis elegans)

Other forms of this molecule

daf-16 [nucleoplasm]

phospho-daf-16 [nucleoplasm]

phospho-daf-16 [cytosol]

daf-16 [nucleoplasm]

daf-16 [mitochondrial matrix]

daf-16 [cytosol]

phospho-daf-16 [cytosol]

phospho-daf-16 [nucleoplasm]

Inferred From

PolyUb-FOXO4 [nucleoplasm] (Homo sapiens)

Modified Residues

Name

ubiquitinylated lysine (PolyUb [cytosol]) at unknown position

Modification

PolyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001021594.1, NP_001021593.1, NP_001021597.1, NP_001021595.1, NP_001251490.1, NP_001021596.1, NP_001021598.2

ENSEMBL

R13H8.1h.1, WBGene00000912, R13H8.1h.1

PRO

O16850

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q17941	20	phospho-p-T309,S474-AKT2 [nucleoplasm] (R-CEL-202087) phospho-p-T305,S472-AKT3 [nucleoplasm] (R-CEL-3009365) phospho-p-T308,S473-AKT1 [nucleoplasm] (R-CEL-198357) phospho-p-T305,S472-AKT3 [cytosol] (R-CEL-3009367) phospho-p-T309,S474-AKT2 [cytosol] (R-CEL-202062) phospho-p-T308,S473-AKT1 [cytosol] (R-CEL-198356) phospho-p-S474-AKT2 [plasma membrane] (R-CEL-2317312) phospho-p-S472-AKT3 [plasma membrane] (R-CEL-3009363) phospho-p-S473-AKT1 [plasma membrane] (R-CEL-377265) AKT2 [plasma membrane] (R-CEL-202053) AKT3 [plasma membrane] (R-CEL-2976006) AKT1 [plasma membrane] (R-CEL-199416) AKT2 [cytosol] (R-CEL-49859) AKT3 [cytosol] (R-CEL-2976007) AKT1 [cytosol] (R-CEL-58252) phospho-p-T309-AKT2 [cytosol] (R-CEL-202066) phospho-p-T305-AKT3 [cytosol] (R-CEL-3009370) phospho-p-T308-AKT1 [cytosol] (R-CEL-198634) phospho-p-Y315,Y326-AKT1 [cytosol] (R-CEL-8848757) phospho-p-T308,S473-AKT1 [plasma membrane] (R-CEL-199430)	0.676	3
UniProt:Q2PJ68	6	SGK3 [cytosol] (R-CEL-2682351) SGK2 [cytosol] (R-CEL-2682364) SGK1 [cytosol] (R-CEL-2682356) phospho-p-S422-SGK1 [cytosol] (R-CEL-6795313) phospho-p-T256,S422-SGK1 [cytosol] (R-CEL-6795449) phospho-p-T256,S422-SGK1 [nucleoplasm] (R-CEL-9612512)	0.676	3
UniProt:Q9XTG7	15	phospho-p-S473-AKT1 [cytosol] (R-CEL-9841264-2) phospho-p-T308,S473-AKT1 [plasma membrane] (R-CEL-199430-2) phospho-p-Y315,Y326-AKT1 [cytosol] (R-CEL-8848757-2) phospho-p-T308-AKT1 [cytosol] (R-CEL-198634-2) phospho-p-T309-AKT2 [cytosol] (R-CEL-202066-2) AKT1 [cytosol] (R-CEL-58252-2) AKT2 [cytosol] (R-CEL-49859-2) AKT1 [plasma membrane] (R-CEL-199416-2) AKT2 [plasma membrane] (R-CEL-202053-2) phospho-p-S473-AKT1 [plasma membrane] (R-CEL-377265-2) phospho-p-S474-AKT2 [plasma membrane] (R-CEL-2317312-2) phospho-p-T308,S473-AKT1 [cytosol] (R-CEL-198356-2) phospho-p-T309,S474-AKT2 [cytosol] (R-CEL-202062-2) phospho-p-T308,S473-AKT1 [nucleoplasm] (R-CEL-198357-2) phospho-p-T309,S474-AKT2 [nucleoplasm] (R-CEL-202087-2)	0.676	3
UniProt:Q21921	1	SIRT1 [nucleoplasm] (R-CEL-427531)	0.589	2
IntAct:EBI-16221250 HCF1			0.524	2
UniProt:Q9N5V3 Q9N5V3			0.488	2

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