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sir-2.1 [nucleoplasm]
Stable Identifier
R-CEL-427531
Type
Protein [EntityWithAccessionedSequence]
Species
Caenorhabditis elegans
Compartment
nucleoplasm
Synonyms
SIRT1, Q21921
Locations in the PathwayBrowser
Expand all
Developmental Biology (Caenorhabditis elegans)
MITF-M-regulated melanocyte development (Caenorhabditis elegans)
Transcriptional and post-translational regulation of MITF-M expression and activity (Caenorhabditis elegans)
HINT1 binds MITF-M (Caenorhabditis elegans)
sir-2.1 [nucleoplasm] (Caenorhabditis elegans)
SIRT1 deacetylates HINT1 dimer (Caenorhabditis elegans)
sir-2.1 [nucleoplasm] (Caenorhabditis elegans)
Gene expression (Transcription) (Caenorhabditis elegans)
RNA Polymerase II Transcription (Caenorhabditis elegans)
Generic Transcription Pathway (Caenorhabditis elegans)
FOXO-mediated transcription (Caenorhabditis elegans)
Regulation of FOXO transcriptional activity by acetylation (Caenorhabditis elegans)
SIRT1,SIRT3 deacetylate FOXO3 (Caenorhabditis elegans)
sir-2.1 [nucleoplasm] (Caenorhabditis elegans)
External Reference Information
External Reference
UniProt:Q21921
Gene Names
sir-2.1
Reference Genes
BioGPS Gene:177924 sir-2.1
CTD Gene:177924 sir-2.1
ENSEMBL:WBGene00004800
KEGG:cel:CELE_R11A8.4 sir-2.1
Monarch:177924 sir-2.1
NCBI Gene:177924 sir-2.1
UCSC:Q21921 sir-2.1
Wormbase:WBGene00004800
Wormbase:WBGene00004800 sir-2.1
Reference Transcript
RefSeq:NM_001268555.5 sir-2.1
Other Identifiers
177924
GO:0000781
GO:0002039
GO:0003714
GO:0003824
GO:0004407
GO:0005515
GO:0005634
GO:0005637
GO:0005654
GO:0005737
GO:0006325
GO:0006355
GO:0008340
GO:0008630
GO:0010468
GO:0010628
GO:0016740
GO:0016787
GO:0017136
GO:0019213
GO:0031507
GO:0032041
GO:0033553
GO:0034605
GO:0034979
GO:0040024
GO:0043226
GO:0045892
GO:0046872
GO:0046969
GO:0046970
GO:0048471
GO:0048856
GO:0051457
GO:0060090
GO:0070403
GO:0097372
GO:0140096
GO:0140110
GO:0140765
GO:0141051
GO:0141222
Participates
as a component of
SIRT1:HSP70:DNAJB1:Ac-K80-HSF1:target gene [nucleoplasm] (Caenorhabditis elegans)
This entity regulates
Positively
HINT1 binds MITF-M
(Caenorhabditis elegans)
Inferred From
SIRT1,SIRT3 [nucleoplasm]
(Homo sapiens)
SIRT1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_001255484.1
ENSEMBL
WBGene00004800
,
R11A8.4a.1
,
R11A8.4a.1
PRO
Q21921
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P41932
5
par-5 [nucleoplasm]
(R-CEL-450469)
par-5 [cytosol]
(R-CEL-1445105)
par-5 [cytosol]
(R-CEL-1445116)
par-5 [cytosol]
(R-CEL-48888)
par-5 [cytosol]
(R-CEL-380312)
0.656
3
UniProt:Q20655
6
ftt-2 [nucleoplasm]
(R-CEL-450469-2)
ftt-2 [cytosol]
(R-CEL-1445105-2)
ftt-2 [cytosol]
(R-CEL-1445107)
ftt-2 [cytosol]
(R-CEL-1445116-2)
ftt-2 [cytosol]
(R-CEL-48888-2)
ftt-2 [cytosol]
(R-CEL-380312-2)
0.632
3
UniProt:O16850
19
daf-16 [nucleoplasm]
(R-CEL-5690183)
daf-16 [nucleoplasm]
(R-CEL-199300)
daf-16 [nucleoplasm]
(R-CEL-199305)
daf-16 [nucleoplasm]
(R-CEL-9614396)
phospho-daf-16 [nucleoplasm]
(R-CEL-9614995)
phospho-daf-16 [nucleoplasm]
(R-CEL-199314)
phospho-daf-16 [nucleoplasm]
(R-CEL-199306)
phospho-daf-16 [nucleoplasm]
(R-CEL-199289)
phospho-daf-16 [cytosol]
(R-CEL-9614413)
phospho-daf-16 [cytosol]
(R-CEL-211158)
phospho-daf-16 [cytosol]
(R-CEL-9614415)
daf-16 [nucleoplasm]
(R-CEL-9620514)
daf-16 [mitochondrial matrix]
(R-CEL-9841849)
daf-16 [mitochondrial matrix]
(R-CEL-9841824)
daf-16 [cytosol]
(R-CEL-5687032)
daf-16 [nucleoplasm]
(R-CEL-6782501)
phospho-daf-16 [cytosol]
(R-CEL-5687014)
phospho-daf-16 [nucleoplasm]
(R-CEL-5687010)
phospho-daf-16 [nucleoplasm]
(R-CEL-5692651)
0.589
2
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