Reactome | sir-2.1 [nucleoplasm]

sir-2.1 [nucleoplasm]

Stable Identifier

R-CEL-427531

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

SIRT1, Q21921

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Caenorhabditis elegans)

- RNA Polymerase II Transcription (Caenorhabditis elegans)
  - Generic Transcription Pathway (Caenorhabditis elegans)
    - FOXO-mediated transcription (Caenorhabditis elegans)
      - Regulation of FOXO transcriptional activity by acetylation (Caenorhabditis elegans)
        
        SIRT1,SIRT3 deacetylate FOXO3 (Caenorhabditis elegans)
        
        sir-2.1 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q21921

Gene Names

sir-2.1

Reference Genes

BioGPS Gene:177924 sir-2.1

CTD Gene:177924 sir-2.1

ENSEMBL:WBGene00004800

KEGG:cel:CELE_R11A8.4 sir-2.1

Monarch:177924 sir-2.1

NCBI Gene:177924 sir-2.1

UCSC:Q21921 sir-2.1

Wormbase:WBGene00004800

Wormbase:WBGene00004800 sir-2.1

Reference Transcript

RefSeq:NM_001268555.5 sir-2.1

Other Identifiers

177924

GO:0000781

GO:0002039

GO:0003714

GO:0003824

GO:0004407

GO:0005515

GO:0005634

GO:0005637

GO:0005654

GO:0005737

GO:0006325

GO:0006355

GO:0008340

GO:0008630

GO:0010468

GO:0010628

GO:0016740

GO:0016787

GO:0017136

GO:0019213

GO:0031507

GO:0032041

GO:0033553

GO:0034605

GO:0034979

GO:0040024

GO:0043226

GO:0045892

GO:0046872

GO:0046969

GO:0046970

GO:0048471

GO:0048856

GO:0051457

GO:0060090

GO:0070403

GO:0097372

GO:0140096

GO:0140110

GO:0140765

GO:0141051

GO:0141222

Participates

as a component of

SIRT1:HSP70:DNAJB1:Ac-K80-HSF1:target gene [nucleoplasm] (Caenorhabditis elegans)

This entity regulates

Positively

HINT1 binds MITF-M (Caenorhabditis elegans)

Inferred From

SIRT1,SIRT3 [nucleoplasm] (Homo sapiens)

SIRT1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001255484.1

ENSEMBL

WBGene00004800, R11A8.4a.1, R11A8.4a.1

PRO

Q21921

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P41932	5	par-5 [nucleoplasm] (R-CEL-450469) par-5 [cytosol] (R-CEL-1445105) par-5 [cytosol] (R-CEL-1445116) par-5 [cytosol] (R-CEL-48888) par-5 [cytosol] (R-CEL-380312)	0.656	3
UniProt:Q20655	6	ftt-2 [nucleoplasm] (R-CEL-450469-2) ftt-2 [cytosol] (R-CEL-1445105-2) ftt-2 [cytosol] (R-CEL-1445107) ftt-2 [cytosol] (R-CEL-1445116-2) ftt-2 [cytosol] (R-CEL-48888-2) ftt-2 [cytosol] (R-CEL-380312-2)	0.632	3
UniProt:O16850	19	daf-16 [nucleoplasm] (R-CEL-5690183) daf-16 [nucleoplasm] (R-CEL-199300) daf-16 [nucleoplasm] (R-CEL-199305) daf-16 [nucleoplasm] (R-CEL-9614396) phospho-daf-16 [nucleoplasm] (R-CEL-9614995) phospho-daf-16 [nucleoplasm] (R-CEL-199314) phospho-daf-16 [nucleoplasm] (R-CEL-199306) phospho-daf-16 [nucleoplasm] (R-CEL-199289) phospho-daf-16 [cytosol] (R-CEL-9614413) phospho-daf-16 [cytosol] (R-CEL-211158) phospho-daf-16 [cytosol] (R-CEL-9614415) daf-16 [nucleoplasm] (R-CEL-9620514) daf-16 [mitochondrial matrix] (R-CEL-9841849) daf-16 [mitochondrial matrix] (R-CEL-9841824) daf-16 [cytosol] (R-CEL-5687032) daf-16 [nucleoplasm] (R-CEL-6782501) phospho-daf-16 [cytosol] (R-CEL-5687014) phospho-daf-16 [nucleoplasm] (R-CEL-5687010) phospho-daf-16 [nucleoplasm] (R-CEL-5692651)	0.589	2

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