Reactome | Cytoprotection by HMOX1

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Cytoprotection by HMOX1 Show undefined attributes

created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10729080
displayName	Cytoprotection by HMOX1
eventOf	[Pathway:R-XTR-9711123] Cellular response to chemical stress - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:376615] cellular response to oxidative stress
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-XTR-9707587] Regulation of HMOX1 expression and activity - Xenopus tropicalis [Reaction:R-XTR-189398] HMOX1 dimer, HMOX2 cleave heme - Xenopus tropicalis [Reaction:R-XTR-189384] BLVRA:Zn2+, BLVRB reduce BV to BIL - Xenopus tropicalis [Reaction:R-XTR-9709406] CO binds to Cytochrome c oxidase - Xenopus tropicalis [Reaction:R-XTR-163214] Electron transfer from reduced cytochrome c to molecular oxygen - Xenopus tropicalis [Reaction:R-XTR-9709317] CO binds to free ferrohemoglobin - Xenopus tropicalis [Reaction:R-XTR-9707504] H2O2 oxidises ferrohemoglobin to MetHb - Xenopus tropicalis [Reaction:R-XTR-9709360] H2O2 reduces MetHb - Xenopus tropicalis [Reaction:R-XTR-9661405] ABCC1 transports BIL from cytosol to extracellular region (blood) - Xenopus tropicalis [Reaction:R-XTR-9661432] BIL binds ALB - Xenopus tropicalis [BlackBoxEvent:R-XTR-9709883] BIL:ALB scavenges O2.- - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-9707564] Cytoprotection by HMOX1 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Cytoprotection by HMOX1
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9707564
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-9711123] Cellular response to chemical stress
(inferredTo)	[Pathway:R-HSA-9707564] Cytoprotection by HMOX1
(hasEncapsulatedEvent)	[Pathway:R-XTR-9818027] NFE2L2 regulating anti-oxidant/detoxification enzymes

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