Reactome | HMOX1 dimer, HMOX2 cleave heme

Schema > Reaction > Entries

HMOX1 dimer, HMOX2 cleave heme Show undefined attributes

catalystActivity	[CatalystActivity:10663205] heme oxygenase (decyclizing) activity of HMOX1 dimer, HMOX2 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10663207
displayName	HMOX1 dimer, HMOX2 cleave heme
eventOf	[Pathway:R-XTR-189483] Heme degradation - Xenopus tropicalis [Pathway:R-XTR-9707564] Cytoprotection by HMOX1 - Xenopus tropicalis [Pathway:R-XTR-917937] Iron uptake and transport - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-189384] BLVRA:Zn2+, BLVRB reduce BV to BIL - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-189398] HMOX1 dimer, HMOX2 cleave heme - Homo sapiens
input	[SimpleEntity:R-ALL-71185] ferroheme [cytosol] 3 × [SimpleEntity:R-ALL-29364] NADPH [cytosol] 3 × [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	HMOX1 dimer, HMOX2 cleave heme The heme ring is cleaved by heme oxygenase
output	[SimpleEntity:R-ALL-189396] BV [cytosol] [SimpleEntity:R-ALL-189385] CO [cytosol] [SimpleEntity:R-ALL-71067] Fe2+ [cytosol] 3 × [SimpleEntity:R-ALL-29356] H2O [cytosol] 3 × [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-XTR-9661408] FLVCR1-2 transports heme from mitochondrial matrix to cytosol - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-189398
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-9707564] Cytoprotection by HMOX1 [Pathway:R-XTR-189483] Heme degradation [Pathway:R-XTR-917937] Iron uptake and transport
(precedingEvent)	[Reaction:R-XTR-189384] BLVRA:Zn2+, BLVRB reduce BV to BIL
(inferredTo)	[Reaction:R-HSA-189398] HMOX1 dimer, HMOX2 cleave heme