Reactome | Electron transfer from reduced cytochrome c to molecular oxygen

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Electron transfer from reduced cytochrome c to molecular oxygen Show undefined attributes

catalystActivity	[CatalystActivity:10660312] cytochrome-c oxidase activity of Cytochrome c oxidase [mitochondrial inner membrane]
category	transition
compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:17927] mitochondrial intermembrane space [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10660320
displayName	Electron transfer from reduced cytochrome c to molecular oxygen
eventOf	[Pathway:R-XTR-9707564] Cytoprotection by HMOX1 - Xenopus tropicalis [Pathway:R-XTR-611105] Respiratory electron transport - Xenopus tropicalis [Pathway:R-XTR-5628897] TP53 Regulates Metabolic Genes - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-9864415] AAC1 imports a proton - Xenopus tropicalis [Reaction:R-XTR-170026] UCP1 imports a proton - Xenopus tropicalis
goBiologicalProcess	[GO_BiologicalProcess:15815] mitochondrial electron transport, cytochrome c to oxygen
inferredFrom	[Reaction:R-HSA-163214] Electron transfer from reduced cytochrome c to molecular oxygen - Homo sapiens
input	4 × [EntityWithAccessionedSequence:R-XTR-352609] Cytochrome c (reduced) [mitochondrial inner membrane] 12 × [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-113533] O2 [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	Electron transfer from reduced cytochrome c to molecular oxygen
output	4 × [EntityWithAccessionedSequence:R-XTR-352607] Cytochrome c (oxidised) [mitochondrial inner membrane] 8 × [SimpleEntity:R-ALL-163953] H+ [mitochondrial intermembrane space] 2 × [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix]
precedingEvent	[Reaction:R-XTR-9866217] HCCS inserts heme into cytochrome c - Xenopus tropicalis
regulatedBy	[NegativeRegulation:10660321] Negative regulation by 'Cytochrome c oxidase:CO [mitochondrial inner membrane]' [PositiveRegulation:10660322] Positive regulation by 'HIGD1C [mitochondrial inner membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-163214
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-9707564] Cytoprotection by HMOX1 [Pathway:R-XTR-5628897] TP53 Regulates Metabolic Genes [Pathway:R-XTR-611105] Respiratory electron transport
(precedingEvent)	[Reaction:R-XTR-9864415] AAC1 imports a proton [Reaction:R-XTR-170026] UCP1 imports a proton
(inferredTo)	[Reaction:R-HSA-163214] Electron transfer from reduced cytochrome c to molecular oxygen