Reactome | Urea cycle

Schema > Pathway > Entries

Urea cycle Show undefined attributes

created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10728482
displayName	Urea cycle
eventOf	[Pathway:R-XTR-71291] Metabolism of amino acids and derivatives - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:20612] urea cycle
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-XTR-70542] glutamate + acetyl CoA => N-acetyl glutamate + CoA - Xenopus tropicalis [Reaction:R-XTR-70555] 2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] - Xenopus tropicalis [Reaction:R-XTR-70560] carbamoyl phosphate + ornithine => citrulline + orthophosphate - Xenopus tropicalis [Reaction:R-XTR-70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - Xenopus tropicalis [Reaction:R-XTR-70573] argininosuccinate <=> fumarate + arginine - Xenopus tropicalis [Reaction:R-XTR-70569] arginine + H2O => ornithine + urea [ARG1] - Xenopus tropicalis [Reaction:R-XTR-452036] arginine + H2O => ornithine + urea [ARG2] - Xenopus tropicalis [Reaction:R-XTR-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) - Xenopus tropicalis [BlackBoxEvent:R-XTR-9956502] OTC precursor is targeted to the mitochondrial matrix and processed - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-70635] Urea cycle - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Urea cycle Urea synthesis
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-70635
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-71291] Metabolism of amino acids and derivatives
(inferredTo)	[Pathway:R-HSA-70635] Urea cycle

© 2026 Reactome

Cite Us!