Reactome | carbamoyl phosphate + ornithine => citrulline + orthophosphate

Schema > Reaction > Entries

carbamoyl phosphate + ornithine => citrulline + orthophosphate Show undefined attributes

catalystActivity	[CatalystActivity:10652762] ornithine carbamoyltransferase activity of OTC trimer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10652764
displayName	carbamoyl phosphate + ornithine => citrulline + orthophosphate
eventOf	[Pathway:R-XTR-70635] Urea cycle - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-70560] carbamoyl phosphate + ornithine => citrulline + orthophosphate - Homo sapiens
input	[SimpleEntity:R-ALL-29676] CAP [mitochondrial matrix] [SimpleEntity:R-ALL-113585] L-Orn [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	carbamoyl phosphate + ornithine => citrulline + orthophosphate
output	[SimpleEntity:R-ALL-113567] L-Cit [mitochondrial matrix] [SimpleEntity:R-ALL-113548] Pi [mitochondrial matrix]
precedingEvent	[Reaction:R-XTR-70555] 2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] - Xenopus tropicalis [Reaction:R-XTR-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) - Xenopus tropicalis [Reaction:R-XTR-70666] glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] - Xenopus tropicalis [BlackBoxEvent:R-XTR-9956502] OTC precursor is targeted to the mitochondrial matrix and processed - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-70560
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-70635] Urea cycle
(precedingEvent)	[Reaction:R-XTR-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)
(inferredTo)	[Reaction:R-HSA-70560] carbamoyl phosphate + ornithine => citrulline + orthophosphate