Reactome | 2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial]

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2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] Show undefined attributes

catalystActivity	[CatalystActivity:10652753] carbamoyl-phosphate synthase (ammonia) activity of CPS1 [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10652755
displayName	2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial]
eventOf	[Pathway:R-XTR-70635] Urea cycle - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-70560] carbamoyl phosphate + ornithine => citrulline + orthophosphate - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-70555] 2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] [SimpleEntity:R-ALL-29896] HCO3- [mitochondrial matrix] [SimpleEntity:R-ALL-113561] NH4+ [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] 2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate
output	2 × [SimpleEntity:R-ALL-113581] ADP [mitochondrial matrix] [SimpleEntity:R-ALL-29676] CAP [mitochondrial matrix] [SimpleEntity:R-ALL-113548] Pi [mitochondrial matrix]
precedingEvent	[Reaction:R-XTR-70542] glutamate + acetyl CoA => N-acetyl glutamate + CoA - Xenopus tropicalis [Reaction:R-XTR-73591] conversion of 3-ureidopropionate to beta-alanine - Xenopus tropicalis
regulatedBy	[PositiveRegulation:R-HSA-70556] Positive regulation by 'NAcGlu [mitochondrial matrix]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-70555
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-70635] Urea cycle
(precedingEvent)	[Reaction:R-XTR-70560] carbamoyl phosphate + ornithine => citrulline + orthophosphate
(inferredTo)	[Reaction:R-HSA-70555] 2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial]

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