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ep300 [nucleoplasm]
Stable Identifier
R-XTR-381325
Type
Protein [EntityWithAccessionedSequence]
Species
Xenopus tropicalis
Compartment
nucleoplasm
Synonyms
EP300, F7DX95
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Xenopus tropicalis)
Cellular responses to stress (Xenopus tropicalis)
Cellular response to chemical stress (Xenopus tropicalis)
KEAP1-NFE2L2 pathway (Xenopus tropicalis)
Nuclear events mediated by NFE2L2 (Xenopus tropicalis)
CREBBP, EP300 acetylates NFE2L2 (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
p-AcK-NFE2L2:CREBBP, EP300 [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
p-NFE2L2:CREBBP,EP300 [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
NFE2L2 binds CREBBP,EP300 (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
p-NFE2L2:CREBBP,EP300 [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
Chromatin organization (Xenopus tropicalis)
Chromatin modifying enzymes (Xenopus tropicalis)
HATs acetylate histones (Xenopus tropicalis)
EP300 acetylates histone H2A, H2B, H3, H4 (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
Developmental Biology (Xenopus tropicalis)
MITF-M-regulated melanocyte development (Xenopus tropicalis)
Transcriptional and post-translational regulation of MITF-M expression and activity (Xenopus tropicalis)
MITF-M binds CREBBP,EP300 (Xenopus tropicalis)
MITF-M:CREBBP,EP300 [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
Gene expression (Transcription) (Xenopus tropicalis)
RNA Polymerase II Transcription (Xenopus tropicalis)
Generic Transcription Pathway (Xenopus tropicalis)
FOXO-mediated transcription (Xenopus tropicalis)
Regulation of FOXO transcriptional activity by acetylation (Xenopus tropicalis)
KAT2B,EP300 acetylate FOXO3 under oxidative stress (Xenopus tropicalis)
KAT2B,(EP300) [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
Transcriptional Regulation by TP53 (Xenopus tropicalis)
Regulation of TP53 Activity (Xenopus tropicalis)
Regulation of TP53 Activity through Acetylation (Xenopus tropicalis)
BRD7 binds TP53 and EP300 (Xenopus tropicalis)
BRD7:p-S15,S20-TP53:EP300 [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
BRD7 promotes EP300-mediated acetylation of TP53 (Xenopus tropicalis)
BRD7:Ac-K382,p-S15,S20-TP53:EP300 [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
BRD7:p-S15,S20-TP53:EP300 [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
MTA2-NuRD complex deacetylates TP53 (Xenopus tropicalis)
BRD7:Ac-K382,p-S15,S20-TP53:EP300, KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (Xenopus tropicalis)
BRD7:Ac-K382,p-S15,S20-TP53:EP300 [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,p-S15,S20-TP53, BRD7:p-S15,S20-TP53:EP300 [nucleoplasm] (Xenopus tropicalis)
BRD7:p-S15,S20-TP53:EP300 [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
PI5P Regulates TP53 Acetylation (Xenopus tropicalis)
ING2 recruits EP300 to TP53 (Xenopus tropicalis)
ING2:EP300:p-S15,S20-TP53 Tetramer [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
ING2-bound EP300 acetylates TP53 (Xenopus tropicalis)
ING2:EP300:Ac-K382,p-S15,S20-TP53 Tetramer [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
ING2:EP300:p-S15,S20-TP53 Tetramer [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
Regulation of TP53 Activity through Methylation (Xenopus tropicalis)
PRMT5 binds TTC5 (Xenopus tropicalis)
p-S15,S20-TP53 Tetramer:p-S203,S221-TTC5:EP300:JMY [nucleoplasm] (Xenopus tropicalis)
p-S203,S221-TTC5:EP300:JMY [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
p-S15,S20-TP53 Tetramer:p-S203,S221-TTC5:EP300:JMY:PRMT5 [nucleoplasm] (Xenopus tropicalis)
p-S15,S20-TP53 Tetramer:p-S203,S221-TTC5:EP300:JMY [nucleoplasm] (Xenopus tropicalis)
p-S203,S221-TTC5:EP300:JMY [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
PRMT5 methylates TP53 (Xenopus tropicalis)
p-S15,S20,Me-R333,Me2-R335,R337-TP53 Tetramer:p-S203,S221-TTC5:EP300:JMY:PRMT5 [nucleoplasm] (Xenopus tropicalis)
p-S203,S221-TTC5:EP300:JMY [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
p-S15,S20-TP53 Tetramer:p-S203,S221-TTC5:EP300:JMY:PRMT5 [nucleoplasm] (Xenopus tropicalis)
p-S15,S20-TP53 Tetramer:p-S203,S221-TTC5:EP300:JMY [nucleoplasm] (Xenopus tropicalis)
p-S203,S221-TTC5:EP300:JMY [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
Transcriptional regulation by RUNX1 (Xenopus tropicalis)
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Xenopus tropicalis)
Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Xenopus tropicalis)
H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Xenopus tropicalis)
H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Xenopus tropicalis)
H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Xenopus tropicalis)
H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
Immune System (Xenopus tropicalis)
Innate Immune System (Xenopus tropicalis)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Xenopus tropicalis)
TRAF6 mediated IRF7 activation (Xenopus tropicalis)
p-IRF7 dimer interacts with coactivator CBP/p300 (Xenopus tropicalis)
CBP/p300:pIRF7:pIRF7 [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
Metabolism of proteins (Xenopus tropicalis)
Post-translational protein modification (Xenopus tropicalis)
Deubiquitination (Xenopus tropicalis)
Metalloprotease DUBs (Xenopus tropicalis)
MYSM1 deubiquitinates Histone H2A (Xenopus tropicalis)
MYSM1:EP300:KAT2B:Histone H2A [nucleoplasm] (Xenopus tropicalis)
MYSM1:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
MYSM1:EP300:KAT2B:Ub-histone H2A [nucleoplasm] (Xenopus tropicalis)
MYSM1:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
SUMOylation (Xenopus tropicalis)
SUMO E3 ligases SUMOylate target proteins (Xenopus tropicalis)
SUMOylation of transcription cofactors (Xenopus tropicalis)
SUMOylation of EP300 with SUMO1 (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
Signal Transduction (Xenopus tropicalis)
Signaling by Nuclear Receptors (Xenopus tropicalis)
ESR-mediated signaling (Xenopus tropicalis)
Estrogen-dependent gene expression (Xenopus tropicalis)
EP300 is recruited to MYC and BCL2 genes (Xenopus tropicalis)
MYC gene, BCL2 gene:HIST1H2AC nucleosome:ESR1:ESTG:EP300 [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
HATs and coactivators are recruited to the CTSD gene (Xenopus tropicalis)
CTSD gene:ESR1:ESTG:SP1:USF1:USF2:NCOA:EP300:MED1 [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
Histone acetyltransferases are recruited to the TFF1 gene (Xenopus tropicalis)
ESR1:estrogen:TFF1gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1:HATs [nucleoplasm] (Xenopus tropicalis)
histone acetyltransferases [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
histone acetyltransferases [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Xenopus tropicalis)
ESR1:estrogen:ERE:NCOA3:EP300 [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
Signaling by ALK (Xenopus tropicalis)
STAT3 nuclear events downstream of ALK signaling (Xenopus tropicalis)
p-Y705,S727 STAT3 is acetylated (Xenopus tropicalis)
ep300 [nucleoplasm] (Xenopus tropicalis)
External Reference Information
External Reference
UniProt:F7DX95
Gene Names
ep300
Reference Genes
ENSEMBL:ENSXETG00000022974
UCSC:F7DX95 ep300
Reference Transcript
RefSeq:XM_004913798.4 ep300
Other Identifiers
734023
GO:0000123
GO:0003712
GO:0003713
GO:0003824
GO:0004402
GO:0005634
GO:0005694
GO:0005737
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0008270
GO:0016740
GO:0016746
GO:0036211
GO:0043226
GO:0043229
GO:0044877
GO:0045944
GO:0046872
GO:0048511
GO:0050896
GO:0140096
GO:0140110
GO:0140297
Participates
as a member of
histone acetyltransferases [nucleoplasm] (Xenopus tropicalis)
as an input of
HATs and coactivators are recruited to the CTSD gene (Xenopus tropicalis)
NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Xenopus tropicalis)
EP300 is recruited to MYC and BCL2 genes (Xenopus tropicalis)
SUMOylation of EP300 with SUMO1 (Xenopus tropicalis)
MITF-M binds CREBBP,EP300 (Xenopus tropicalis)
NFE2L2 binds CREBBP,EP300 (Xenopus tropicalis)
ING2 recruits EP300 to TP53 (Xenopus tropicalis)
BRD7 binds TP53 and EP300 (Xenopus tropicalis)
p-IRF7 dimer interacts with coactivator CBP/p300 (Xenopus tropicalis)
as a component of
CTSD gene:ESR1:ESTG:SP1:USF1:USF2:NCOA:EP300:MED1 [nucleoplasm] (Xenopus tropicalis)
ESR1:estrogen:ERE:NCOA3:EP300 [nucleoplasm] (Xenopus tropicalis)
MYC gene, BCL2 gene:HIST1H2AC nucleosome:ESR1:ESTG:EP300 [nucleoplasm] (Xenopus tropicalis)
MYSM1:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
MITF-M:CREBBP,EP300 [nucleoplasm] (Xenopus tropicalis)
p-NFE2L2:CREBBP,EP300 [nucleoplasm] (Xenopus tropicalis)
p-AcK-NFE2L2:CREBBP, EP300 [nucleoplasm] (Xenopus tropicalis)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Xenopus tropicalis)
p-S203,S221-TTC5:EP300:JMY [nucleoplasm] (Xenopus tropicalis)
ING2:EP300:Ac-K382,p-S15,S20-TP53 Tetramer [nucleoplasm] (Xenopus tropicalis)
ING2:EP300:p-S15,S20-TP53 Tetramer [nucleoplasm] (Xenopus tropicalis)
BRD7:Ac-K382,p-S15,S20-TP53:EP300 [nucleoplasm] (Xenopus tropicalis)
BRD7:p-S15,S20-TP53:EP300 [nucleoplasm] (Xenopus tropicalis)
CBP/p300:pIRF7:pIRF7 [nucleoplasm] (Xenopus tropicalis)
NOTCH1 Coactivator Complex [nucleoplasm] (Xenopus tropicalis)
as a candidate of
KAT2B,(EP300) [nucleoplasm] (Xenopus tropicalis)
Other forms of this molecule
ep300 [nucleoplasm]
Inferred From
CREBBP,EP300 [nucleoplasm]
(Homo sapiens)
EP300 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
XP_004913855.2
ENSEMBL
ENSXETT00000049703
,
ENSXETP00000049703
Xenbase
XB-GENE-482293
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