Reactome | TNF-? trimer:TNFR1 trimer [plasma membrane]

Schema > DefinedSet > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-SSC-5626996] TNF-?:TNFR1:NSMAF [plasma membrane] - Sus scrofa [Complex:R-SSC-9818791] TNF?:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] - Sus scrofa [Complex:R-SSC-140946] TNF-?:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] - Sus scrofa [Complex:R-SSC-5634184] TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] - Sus scrofa
consumedByEvent	[Reaction:R-SSC-5626988] TNF-?:TNFR1 binds NSMAF - Sus scrofa [Reaction:R-SSC-5626953] TNF-?:TNFR1 binds DENN/MADD - Sus scrofa [Reaction:R-SSC-83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - Sus scrofa [Reaction:R-SSC-5634221] TRAF1 binds TRAF2 within TNFR1 signaling complex - Sus scrofa
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10453523
displayName	TNF-? trimer:TNFR1 trimer [plasma membrane]
hasMember	[Complex:R-SSC-74277] TNF-?:TNFR1 [plasma membrane] - Sus scrofa [Complex:R-SSC-3371397] soluble TNF-?:TNFR1 [plasma membrane] - Sus scrofa
inDisease	false
inferredFrom	[DefinedSet:R-HSA-3371401] TNF-? trimer:TNFR1 trimer [plasma membrane] - Homo sapiens
maxDepth	4
name	TNF-? trimer:TNFR1 trimer
producedByEvent	[Reaction:R-SSC-83582] TRADD:TRAF2:RIP1 dissociates from TNF-?:TNFR1 - Sus scrofa
schemaClass	DefinedSet
species	[Species:49633] Sus scrofa
stId	R-SSC-3371401

(input)	[Reaction:R-SSC-5626988] TNF-?:TNFR1 binds NSMAF [Reaction:R-SSC-5634221] TRAF1 binds TRAF2 within TNFR1 signaling complex [Reaction:R-SSC-5626953] TNF-?:TNFR1 binds DENN/MADD [Reaction:R-SSC-83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1
(hasComponent)	[Complex:R-SSC-5626996] TNF-?:TNFR1:NSMAF [plasma membrane] [Complex:R-SSC-9818791] TNF?:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] [Complex:R-SSC-5634184] TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] [Complex:R-SSC-5626965] TNF-?:TNFR1:DENN-SV,MADD [plasma membrane] [Complex:R-SSC-9817409] TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] [Complex:R-SSC-9793688] TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] [Complex:R-SSC-9817363] TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] [Complex:R-SSC-5357756] TNF-?:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] [Complex:R-SSC-9816109] TNF-?:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] [Complex:R-SSC-9817389] TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] [Complex:R-SSC-140946] TNF-?:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane]
(output)	[Reaction:R-SSC-83582] TRADD:TRAF2:RIP1 dissociates from TNF-?:TNFR1
(inferredTo)	[DefinedSet:R-HSA-3371401] TNF-? trimer:TNFR1 trimer [plasma membrane]

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