Reactome | TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10453599
displayName	TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane]
hasComponent	[CandidateSet:R-SSC-5357900] BIRC2,3,4 [cytosol] [Complex:R-SSC-9796690] CYLD:SPATA2:LUBAC [cytosol] [DefinedSet:R-SSC-9730454] p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] [EntityWithAccessionedSequence:R-SSC-9817377] phospho-RIPK1 [cytosol] [DefinedSet:R-SSC-3371401] TNF-? trimer:TNFR1 trimer [plasma membrane] 3 × [EntityWithAccessionedSequence:R-SSC-66376] TRADD [cytosol] 3 × [EntityWithAccessionedSequence:R-SSC-66370] TRAF2 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-9817389] TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] - Homo sapiens
maxDepth	5
name	TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE
negativelyRegulates	[NegativeRegulation:10453603] Negative regulation by 'TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane]'
producedByEvent	[Reaction:R-SSC-9817397] TBK1, IKBKE phosphorylate RIPK1 at T189 - Sus scrofa
schemaClass	Complex
species	[Species:49633] Sus scrofa
stId	R-SSC-9817389
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(output)	[Reaction:R-SSC-9817397] TBK1, IKBKE phosphorylate RIPK1 at T189
(regulator)	[NegativeRegulation:10453603] Negative regulation by 'TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane]'
(inferredTo)	[Complex:R-HSA-9817389] TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane]

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