Reactome | TNF-?:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10453538
displayName	TNF-?:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane]
hasComponent	[EntityWithAccessionedSequence:R-SSC-1472879] MIB2 [cytosol] [EntityWithAccessionedSequence:R-SSC-9818391] RIPK1 [cytosol] [DefinedSet:R-SSC-3371401] TNF-? trimer:TNFR1 trimer [plasma membrane] 3 × [EntityWithAccessionedSequence:R-SSC-66376] TRADD [cytosol] 3 × [EntityWithAccessionedSequence:R-SSC-66370] TRAF2 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-9816109] TNF-?:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] - Homo sapiens
maxDepth	5
name	TNF-?:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2
negativelyRegulates	[NegativeRegulation:10453602] Negative regulation by 'TNF-?:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane]'
producedByEvent	[BlackBoxEvent:R-SSC-9796346] MIB2 ubiquitinates RIPK1 at K377, K604, K634 - Sus scrofa
schemaClass	Complex
species	[Species:49633] Sus scrofa
stId	R-SSC-9816109
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(output)	[BlackBoxEvent:R-SSC-9796346] MIB2 ubiquitinates RIPK1 at K377, K604, K634
(regulator)	[NegativeRegulation:10453602] Negative regulation by 'TNF-?:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane]'
(inferredTo)	[Complex:R-HSA-9816109] TNF-?:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane]

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