Reactome | TNF-?:TNFR1 binds DENN/MADD

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TNF-?:TNFR1 binds DENN/MADD Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10516162
displayName	TNF-?:TNFR1 binds DENN/MADD
eventOf	[Pathway:R-SSC-5357905] Regulation of TNFR1 signaling - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5626953] TNF-?:TNFR1 binds DENN/MADD - Homo sapiens
input	[EntityWithAccessionedSequence:R-SSC-5626960] MADD [cytosol] [DefinedSet:R-SSC-3371401] TNF-? trimer:TNFR1 trimer [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	TNF-?:TNFR1 binds DENN/MADD
output	[Complex:R-SSC-5626965] TNF-?:TNFR1:DENN-SV,MADD [plasma membrane]
precedingEvent	[Reaction:R-SSC-83660] Membrane-anchored TNF-? binds TNFR1 - Sus scrofa [Reaction:R-SSC-3371353] Soluble TNF-? binds TNFR1 - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-5626953
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-5357905] Regulation of TNFR1 signaling
(inferredTo)	[Reaction:R-HSA-5626953] TNF-?:TNFR1 binds DENN/MADD

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