Reactome | MAD2L1 [cytosol]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-SSC-141408] MAD2CDC20 complex [cytosol] - Sus scrofa [Complex:R-SSC-141427] Kinetochore:Mad1:MAD2 Complex [cytosol] - Sus scrofa [Complex:R-SSC-174196] hBUBR1:hBUB3:MAD2 complex [cytosol] - Sus scrofa
consumedByEvent	[Reaction:R-SSC-141429] Inactivation of APC/C via CDC20 sequestration - Sus scrofa [Reaction:R-SSC-141431] MAD2 associates with the Mad1 kinetochore complex - Sus scrofa [Reaction:R-SSC-141437] Formation of the MCC complex - Sus scrofa
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10456857
displayName	MAD2L1 [cytosol]
endCoordinate	205
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-141447] Activated MAD2L1 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-141400] MAD2L1 [cytosol] - Homo sapiens
maxDepth	1
name	MAD2L1 MAD2L1 A0A286ZJ52
producedByEvent	[Reaction:R-SSC-141439] Release of activated MAD2 from kinetochores - Sus scrofa
referenceEntity	[ReferenceGeneProduct:uniprot:A0A286ZJ52] UniProt:A0A286ZJ52
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:49633] Sus scrofa
stId	R-SSC-141400
startCoordinate	2

(input)	[Reaction:R-SSC-141429] Inactivation of APC/C via CDC20 sequestration [Reaction:R-SSC-141437] Formation of the MCC complex [Reaction:R-SSC-141431] MAD2 associates with the Mad1 kinetochore complex
(hasComponent)	[Complex:R-SSC-141408] MAD2CDC20 complex [cytosol] [Complex:R-SSC-174196] hBUBR1:hBUB3:MAD2 complex [cytosol] [Complex:R-SSC-141427] Kinetochore:Mad1:MAD2 Complex [cytosol] [Complex:R-SSC-377882] Mitotic checkpoint complex [cytosol]
(output)	[Reaction:R-SSC-141439] Release of activated MAD2 from kinetochores
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-141447] Activated MAD2L1 [cytosol] [EntityWithAccessionedSequence:R-HSA-141400] MAD2L1 [cytosol]