Reactome | Release of activated MAD2 from kinetochores

Schema > Reaction > Entries

Release of activated MAD2 from kinetochores Show undefined attributes

category	dissociation
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10456953
displayName	Release of activated MAD2 from kinetochores
eventOf	[Pathway:R-SSC-141444] Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-141429] Inactivation of APC/C via CDC20 sequestration - Sus scrofa [Pathway:R-SSC-141430] Inactivation of APC/C via direct inhibition of the APC/C complex - Sus scrofa [Reaction:R-SSC-141437] Formation of the MCC complex - Sus scrofa
inferredFrom	[Reaction:R-HSA-141439] Release of activated MAD2 from kinetochores - Homo sapiens
input	[Complex:R-SSC-141427] Kinetochore:Mad1:MAD2 Complex [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Release of activated MAD2 from kinetochores
output	[Complex:R-SSC-141441] Mad1:kinetochore complex [cytosol] [EntityWithAccessionedSequence:R-SSC-141400] MAD2L1 [cytosol]
precedingEvent	[Reaction:R-SSC-141422] MAD2 converted to an inhibitory state via interaction with Mad1 - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-141439
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-SSC-141429] Inactivation of APC/C via CDC20 sequestration [Pathway:R-SSC-141430] Inactivation of APC/C via direct inhibition of the APC/C complex [Reaction:R-SSC-141437] Formation of the MCC complex
(hasEvent)	[Pathway:R-SSC-141444] Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
(inferredTo)	[Reaction:R-HSA-141439] Release of activated MAD2 from kinetochores