Reactome | Co-stimulation by CD28

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Co-stimulation by CD28 Show undefined attributes

created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10557159
displayName	Co-stimulation by CD28
eventOf	[Pathway:R-SSC-388841] Regulation of T cell activation by CD28 family - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:173020] T cell costimulation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-SSC-388811] CD28 homodimer binds B7-1 homodimer - Sus scrofa [Reaction:R-SSC-388808] CD28 homodimer binds B7-2 monomer - Sus scrofa [Reaction:R-SSC-388831] Phosphorylation of CD28 - Sus scrofa [Reaction:R-SSC-389381] Gads binds CD28 - Sus scrofa [Pathway:R-SSC-389357] CD28 dependent PI3K/Akt signaling - Sus scrofa [Pathway:R-SSC-389359] CD28 dependent Vav1 pathway - Sus scrofa
inferredFrom	[Pathway:R-HSA-389356] Co-stimulation by CD28 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Co-stimulation by CD28 CD28 co-stimulation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-389356
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-388841] Regulation of T cell activation by CD28 family
(hasEncapsulatedEvent)	[Pathway:R-SSC-389513] Co-inhibition by CTLA4
(inferredTo)	[Pathway:R-HSA-389356] Co-stimulation by CD28

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