Reactome | Co-stimulation by ICOS

Schema > Pathway > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10557167
displayName	Co-stimulation by ICOS
eventOf	[Pathway:R-SSC-388841] Regulation of T cell activation by CD28 family - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:173020] T cell costimulation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-SSC-388817] ICOS binds ICOSL/B7-H2 - Sus scrofa [Reaction:R-SSC-388830] PI3K binds ICOS - Sus scrofa
inferredFrom	[Pathway:R-HSA-9927354] Co-stimulation by ICOS - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Co-stimulation by ICOS ICOS co-stimulation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-9927354
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-SSC-388841] Regulation of T cell activation by CD28 family
(inferredTo)	[Pathway:R-HSA-9927354] Co-stimulation by ICOS

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