Reactome | SQSTM1 [cytosol]

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SQSTM1 [cytosol] Show undefined attributes

catalystActivities	[CatalystActivity:10127060] ubiquitin binding activity of SQSTM1 [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-RNO-9759097] SQSTM1 oligomer [cytosol] - Rattus norvegicus [Complex:R-RNO-9759097] SQSTM1 oligomer [cytosol] - Rattus norvegicus [Complex:R-RNO-9759097] SQSTM1 oligomer [cytosol] - Rattus norvegicus [Complex:R-RNO-209565] NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-9759154] TRIM21 ubiquitinates SQSTM1 - Rattus norvegicus [Reaction:R-RNO-9759158] SQSTM1 oligomerizes - Rattus norvegicus [Reaction:R-RNO-9759158] SQSTM1 oligomerizes - Rattus norvegicus [Reaction:R-RNO-9759158] SQSTM1 oligomerizes - Rattus norvegicus [Reaction:R-RNO-9664892] SQSTM1 binds ATM dimer:Ub-p-PEX5 - Rattus norvegicus [Reaction:R-RNO-5205673] p62 binds ubiquitinated mitochondrial substrates - Rattus norvegicus [Reaction:R-RNO-193694] p62 is recruited and forms a complex with TRAF6 - Rattus norvegicus [Reaction:R-RNO-205008] Polyubiquitinated NRIF binds to p62 (Sequestosome) - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10122410
displayName	SQSTM1 [cytosol]
endCoordinate	440
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-193937] SQSTM1 [cytosol] - Homo sapiens
maxDepth	1
name	SQSTM1 O08623
referenceEntity	[ReferenceGeneProduct:uniprot:O08623] UniProt:O08623
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48895] Rattus norvegicus
stId	R-RNO-193937
startCoordinate	1

Referrals

(input)	[Reaction:R-RNO-9759154] TRIM21 ubiquitinates SQSTM1 [Reaction:R-RNO-9759158] SQSTM1 oligomerizes [Reaction:R-RNO-193694] p62 is recruited and forms a complex with TRAF6 [Reaction:R-RNO-205008] Polyubiquitinated NRIF binds to p62 (Sequestosome) [Reaction:R-RNO-9664892] SQSTM1 binds ATM dimer:Ub-p-PEX5 [Reaction:R-RNO-5205673] p62 binds ubiquitinated mitochondrial substrates
(hasComponent)	[Complex:R-RNO-9759097] SQSTM1 oligomer [cytosol] [Complex:R-RNO-209565] NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] [Complex:R-RNO-209542] NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] [Complex:R-RNO-209577] NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] [Complex:R-RNO-205035] Ubiquitinated NRIF:Sequestosome [cytosol] [Complex:R-RNO-507714] MAP3K3:SQSTM1 [cytosol] [Complex:R-RNO-9665168] ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] [Complex:R-RNO-5205659] K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane]
(physicalEntity)	[CatalystActivity:10127060] ubiquitin binding activity of SQSTM1 [cytosol]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-193937] SQSTM1 [cytosol]

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