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Schema
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Reaction
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Entries
TRIM21 ubiquitinates SQSTM1
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authored
[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
catalystActivity
[CatalystActivity:9759151] ubiquitin protein ligase activity of TRIM21 [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:9759153] Rothfels, Karen, 2021-11-29
dbId
9759154
displayName
TRIM21 ubiquitinates SQSTM1
edited
[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
eventOf
[Pathway:R-HSA-9755511] KEAP1-NFE2L2 pathway - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-193937] SQSTM1 [cytosol]
3 ×
[DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9759025] TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis
[LiteratureReference:9708494] The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway
maxDepth
1
modified
[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name
TRIM21 ubiquitinates SQSTM1
orthologousEvent
[Reaction:R-MMU-9759154] TRIM21 ubiquitinates SQSTM1 - Mus musculus
[Reaction:R-CEL-9759154] TRIM21 ubiquitinates SQSTM1 - Caenorhabditis elegans
[Reaction:R-GGA-9759154] TRIM21 ubiquitinates SQSTM1 - Gallus gallus
[Reaction:R-DRE-9759154] TRIM21 ubiquitinates SQSTM1 - Danio rerio
[Reaction:R-SSC-9759154] TRIM21 ubiquitinates SQSTM1 - Sus scrofa
[Reaction:R-BTA-9759154] TRIM21 ubiquitinates SQSTM1 - Bos taurus
[Reaction:R-CFA-9759154] TRIM21 ubiquitinates SQSTM1 - Canis familiaris
[Reaction:R-RNO-9759154] TRIM21 ubiquitinates SQSTM1 - Rattus norvegicus
output
[EntityWithAccessionedSequence:R-HSA-9759088] K7 ub-SQSTM1 [cytosol]
precedingEvent
[BlackBoxEvent:R-HSA-9759157] NFE2L2-dependent SQSTM1 gene expression - Homo sapiens
releaseDate
2022-03-23
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9759154
summation
[Summation:9759152] E3 ubiquitin ligase TRIM21 ubiquitinates SQSTM1 at lysine 7,...
Referrals
(hasEvent)
[Pathway:R-HSA-9755511] KEAP1-NFE2L2 pathway
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