Reactome | UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL

Schema > BlackBoxEvent > Entries

UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL Show undefined attributes

catalystActivity	[CatalystActivity:10115202] glucuronosyltransferase activity of UGT1A4 [endoplasmic reticulum membrane]
category	omitted
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10215072
displayName	UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL
eventOf	[Pathway:R-RNO-9754706] Atorvastatin ADME - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-9757139] ABCB1,ABCC2 transport ATVs from cytosol to extracellular region - Rattus norvegicus
inferredFrom	[BlackBoxEvent:R-HSA-9756134] UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL - Homo sapiens
input	[ChemicalDrug:R-ALL-9756322] 2-OH-ATV [cytosol] [SimpleEntity:R-ALL-158601] UDP-GlcA [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL
output	[SimpleEntity:R-ALL-9756330] 2-OH-ATVL [cytosol] [SimpleEntity:R-ALL-2162232] GlcA [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-110096] UDP [cytosol]
precedingEvent	[Reaction:R-RNO-9756169] CYP3A4 monooxygenates ATV to 2-OH-ATV - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9756134
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9754706] Atorvastatin ADME
(precedingEvent)	[Reaction:R-RNO-9757139] ABCB1,ABCC2 transport ATVs from cytosol to extracellular region
(inferredTo)	[BlackBoxEvent:R-HSA-9756134] UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL

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