Reactome | Atorvastatin ADME

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Atorvastatin ADME Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10225379
displayName	Atorvastatin ADME
eventOf	[TopLevelPathway:R-RNO-9748784] Drug ADME - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:8764] xenobiotic metabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-RNO-9757010] SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol - Rattus norvegicus [Reaction:R-RNO-9756169] CYP3A4 monooxygenates ATV to 2-OH-ATV - Rattus norvegicus [Reaction:R-RNO-9756162] CYP3A4 monooxygenates ATV to 4-OH-ATV - Rattus norvegicus [BlackBoxEvent:R-RNO-9756156] UGT1A3 lactonizes ATV to ATVL - Rattus norvegicus [BlackBoxEvent:R-RNO-9756134] UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL - Rattus norvegicus [BlackBoxEvent:R-RNO-9756183] UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL - Rattus norvegicus [Reaction:R-RNO-9756138] CYP3A4 monooxygenates ATVL to 2-OH-ATVL - Rattus norvegicus [Reaction:R-RNO-9756180] CYP3A4 monooxygenates ATVL to 4-OH-ATVL - Rattus norvegicus [Reaction:R-RNO-9756177] PON1,3 hydrolyse ATVL to ATV - Rattus norvegicus [Reaction:R-RNO-9757139] ABCB1,ABCC2 transport ATVs from cytosol to extracellular region - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-9754706] Atorvastatin ADME - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Atorvastatin ADME
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9754706
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[TopLevelPathway:R-RNO-9748784] Drug ADME
(inferredTo)	[Pathway:R-HSA-9754706] Atorvastatin ADME

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