Reactome | Chuk [cytosol]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-RNO-5607705] IKKA dimer [cytosol] - Rattus norvegicus [Complex:R-RNO-5607705] IKKA dimer [cytosol] - Rattus norvegicus [Complex:R-RNO-9909487] FKBP5:CHUK [cytosol] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-9749505] LRRC14 binds IKBKB and CHUK - Rattus norvegicus [Reaction:R-RNO-9750226] NLRC5 binds IKBKB and CHUK - Rattus norvegicus [Reaction:R-RNO-198611] AKT phosphorylates IKKalpha - Rattus norvegicus [Reaction:R-RNO-5609665] CHUK, IKBKB and IKBKG form IKK complex - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10123344
displayName	Chuk [cytosol]
endCoordinate	745
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-168104] CHUK [cytosol] - Homo sapiens
maxDepth	1
name	Chuk CHUK A0A8I6ANR6
producedByEvent	[BlackBoxEvent:R-RNO-9750946] TRAF2,6 ubiquitinates NLRC5 - Rattus norvegicus
referenceEntity	[ReferenceGeneProduct:uniprot:A0A8I6ANR6] UniProt:A0A8I6ANR6
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48895] Rattus norvegicus
stId	R-RNO-168104
startCoordinate	1

(hasComponent)	[Complex:R-RNO-9909487] FKBP5:CHUK [cytosol] [Complex:R-RNO-5607705] IKKA dimer [cytosol] [Complex:R-RNO-9836494] EIF2AK2:CHUK:IKBKB:IKBKG [cytosol] [Complex:R-RNO-202562] CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] [Complex:R-RNO-9749467] CHUK:IKBKB:LRRC14 [cytosol] [Complex:R-RNO-9750228] CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] [Complex:R-RNO-202513] CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] [Complex:R-RNO-168113] CHUK:IKBKB:IKBKG [cytosol]
(input)	[Reaction:R-RNO-198611] AKT phosphorylates IKKalpha [Reaction:R-RNO-9749505] LRRC14 binds IKBKB and CHUK [Reaction:R-RNO-9750226] NLRC5 binds IKBKB and CHUK [Reaction:R-RNO-5609665] CHUK, IKBKB and IKBKG form IKK complex
(output)	[BlackBoxEvent:R-RNO-9750946] TRAF2,6 ubiquitinates NLRC5
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-168104] CHUK [cytosol]