Reactome | Pellino ubiquitinates hp-IRAK1

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Pellino ubiquitinates hp-IRAK1 Show undefined attributes

catalystActivity	[CatalystActivity:10146212] ubiquitin-ubiquitin ligase activity of p-Pellino:hp-IRAK1:TRAF6 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10146214
displayName	Pellino ubiquitinates hp-IRAK1
eventOf	[Pathway:R-RNO-937039] IRAK1 recruits IKK complex - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-937032] NEMO subunit of IKK complex binds to activated IRAK1 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-937050] Pellino ubiquitinates hp-IRAK1 - Homo sapiens
input	2 × [Polymer:R-RNO-450152] K63polyUb [cytosol] [Complex:R-RNO-937020] TRAF6:hp-IRAK1:Pellino [plasma membrane] [Complex:R-RNO-202463] UBE2N:UBE2V1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Pellino ubiquitinates hp-IRAK1
output	[Complex:R-RNO-937043] K63-linked polyUb p-IRAK1:TRAF6 [cytosol] [CandidateSet:R-RNO-450819] p-Pellino-1,2,(3) [cytosol] [Complex:R-RNO-202463] UBE2N:UBE2V1 [cytosol]
precedingEvent	[Reaction:R-RNO-937034] IRAK1 phosphorylates Pellino - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-937050
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-937039] IRAK1 recruits IKK complex
(precedingEvent)	[Reaction:R-RNO-937032] NEMO subunit of IKK complex binds to activated IRAK1
(inferredTo)	[Reaction:R-HSA-937050] Pellino ubiquitinates hp-IRAK1