Reactome | IRAK1 recruits IKK complex

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IRAK1 recruits IKK complex Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10224051
displayName	IRAK1 recruits IKK complex
eventOf	[Pathway:R-RNO-975871] MyD88 cascade initiated on plasma membrane - Rattus norvegicus [Pathway:R-RNO-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:161528] positive regulation of canonical NF-kappaB signal transduction
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-937044] Pellino binds hp-IRAK1:TRAF6 - Rattus norvegicus [Reaction:R-RNO-937034] IRAK1 phosphorylates Pellino - Rattus norvegicus [Reaction:R-RNO-937050] Pellino ubiquitinates hp-IRAK1 - Rattus norvegicus [Reaction:R-RNO-937032] NEMO subunit of IKK complex binds to activated IRAK1 - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-937039] IRAK1 recruits IKK complex - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	IRAK1 recruits IKK complex
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-937039
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane [Pathway:R-RNO-975871] MyD88 cascade initiated on plasma membrane
(inferredTo)	[Pathway:R-HSA-937039] IRAK1 recruits IKK complex