Reactome | Regulated Necrosis

Schema > Pathway > Entries

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10222543
displayName	Regulated Necrosis
eventOf	[TopLevelPathway:R-RNO-5357801] Programmed Cell Death - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:2266699] programmed necrotic cell death
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-RNO-5213460] RIPK1-mediated regulated necrosis - Rattus norvegicus [Pathway:R-RNO-5620971] Pyroptosis - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-5218859] Regulated Necrosis - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	5
name	Regulated Necrosis Programmed necrosis
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5218859
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[TopLevelPathway:R-RNO-5357801] Programmed Cell Death
(hasEncapsulatedEvent)	[Pathway:R-RNO-75893] TNF signaling [Pathway:R-RNO-168164] Toll Like Receptor 3 (TLR3) Cascade [Pathway:R-RNO-166166] MyD88-independent TLR4 cascade
(inferredTo)	[Pathway:R-HSA-5218859] Regulated Necrosis

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