Reactome | Regulation of necroptotic cell death

Schema > Pathway > Entries

Regulation of necroptotic cell death Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10224567
displayName	Regulation of necroptotic cell death
eventOf	[Pathway:R-RNO-5213460] RIPK1-mediated regulated necrosis - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:422731] regulation of necroptotic process
hasDiagram	false
hasEHLD	false
hasEvent	[Pathway:R-RNO-5218900] CASP8 activity is inhibited - Rattus norvegicus [BlackBoxEvent:R-RNO-5675470] BIRC2/3 (cIAP1/2) is autoubiquitinated - Rattus norvegicus [BlackBoxEvent:R-RNO-5357828] RIPK1 is cleaved by CASP8 - Rattus norvegicus [BlackBoxEvent:R-RNO-9686930] RIPK3 is cleaved by CASP8 - Rattus norvegicus [Reaction:R-RNO-9686922] PELI1 binds activated RIPK1:RIPK3 - Rattus norvegicus [BlackBoxEvent:R-RNO-9686920] PELI1 ubiquitinates RIPK3 at K363 - Rattus norvegicus [Reaction:R-RNO-9687625] ATP binds MLKL - Rattus norvegicus [Reaction:R-RNO-9687638] MLKL binds IP4, IP5 and IP6 - Rattus norvegicus [Reaction:R-RNO-9687828] O-GlcNAcylation of RIPK3 (TLR4 signaling) - Rattus norvegicus [Reaction:R-RNO-9688459] RIPK3 binds HSP90:CDC37 - Rattus norvegicus [Reaction:R-RNO-9698844] MLKL binds HSP90:CDC37 - Rattus norvegicus [Reaction:R-RNO-9688456] MLKL binds FLOT1, FLOT2 - Rattus norvegicus [Reaction:R-RNO-9688832] MLKL binds PDCD6IP and SDCBP - Rattus norvegicus [Reaction:R-RNO-9688838] RIPK3 binds STUB1 - Rattus norvegicus [BlackBoxEvent:R-RNO-9688831] STUB1 ubiquitinates RIPK3 at K55, K363 - Rattus norvegicus [Reaction:R-RNO-9693978] Small molecule inhibitor binds RIPK1, RIPK3 - Rattus norvegicus [Reaction:R-RNO-9793451] MLKL binds ITCH - Rattus norvegicus [BlackBoxEvent:R-RNO-9793444] ITCH polyubiquitinates MLKL at K50 - Rattus norvegicus [Reaction:R-RNO-9793472] RIPK3 binds p-S9-PRKN - Rattus norvegicus [BlackBoxEvent:R-RNO-9793485] PRKN polyubiquitinates RIPK3 - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-5675482] Regulation of necroptotic cell death - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Regulation of necroptotic cell death
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5675482
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5213460] RIPK1-mediated regulated necrosis
(inferredTo)	[Pathway:R-HSA-5675482] Regulation of necroptotic cell death

© 2026 Reactome

Cite Us!