Reactome | TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK

Schema > BlackBoxEvent > Entries

TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK Show undefined attributes

catalystActivity	[CatalystActivity:10181894] transferase activity of Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane]
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10181896
displayName	TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK
eventOf	[Pathway:R-RNO-5668541] TNFR2 non-canonical NF-kB pathway - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-RNO-5668454] K63polyUb-cIAP1,2 ubiquitinates TRAF3 - Rattus norvegicus
inferredFrom	[BlackBoxEvent:R-HSA-5668414] TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK - Homo sapiens
input	[Polymer:R-RNO-450152] K63polyUb [cytosol] [DefinedSet:R-RNO-5676554] Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK
output	[Complex:R-RNO-5668433] TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane]
precedingEvent	[Reaction:R-RNO-5668417] cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5668414
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5668541] TNFR2 non-canonical NF-kB pathway
(precedingEvent)	[BlackBoxEvent:R-RNO-5668454] K63polyUb-cIAP1,2 ubiquitinates TRAF3
(inferredTo)	[BlackBoxEvent:R-HSA-5668414] TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK

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